Jobs / United States / Astrazeneca Pharmaceuticals Lp
Associate Principal Scientist, Vaccine Drug Product Development
Astrazeneca Pharmaceuticals Lp · 🇺🇸 US - Gaithersburg - MD
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Astrazeneca Pharmaceuticals Lp paid sponsored hires in similar roles15 certified filings for “Associate Director Oncology Outcomes Research” (Medical Scientists, Except Epidemiologists) in MD: $126k–$185k, median $140k. Most were filed at wage level II (47%) — 2 lottery entries, ≈31% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
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Sponsor Radar — Astrazeneca Pharmaceuticals Lp
The US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Astrazeneca Pharmaceuticals Lp →
About the role
Associate Principal Scientist, Vaccine Drug Product Development Introduction to the Role Join our Vaccines Drug Product Development team to shape the next generation of preventative therapies. We are seeking a highly motivated Associate Principal Scientist with deep experience in vaccine formulation development, adjuvant systems, and complex, co-formulated drug products. You will independently lead the design and development of formulations and drug product processes spanning Phase 1 through pivotal clinical development, with a focus on multi-antigen/adjuvant combinations and other vaccine modalities. You will drive development strategies, influence CMC decisions, provide technical leadership across multidisciplinary teams, manage external partners, and connect near-term deliverables to long-term program and patient impact. Key Responsibilities You will provide independent scientific and technical leadership for vaccine drug product programs from early formulation development through pivotal clinical development and manufacturing readiness. You will define development strategies, integrate formulation, process, analytical, regulatory, and manufacturing considerations, and translate complex data into clear program decisions. Additionally, you will: · Vaccine Formulation and Product Development : Lead formulation development for multi-antigen/adjuvant products and other vaccine modalities. Define studies, selection criteria, and control strategies addressing antigen–adjuvant interactions, compatibility, immunogenicity, and product stability across clinical phases. · Analytical Strategy and Product Characterization : Partner with Analytical Sciences to define fit-for-purpose methods and data expectations for vaccine and adjuvant characterization. Ensure analytical evidence supports formulation selection, process understanding, comparability, and control strategies. · Drug Product Process Design, Scale-Up, and Manufacturing Readiness : Lead development, scale-up, characterization, and robustness studies for vaccine drug product processes. Build process–product understanding, assess risks, and translate processes into reproducible, GMP-ready operations. · GMP Manufacturing and Technology Transfer : Lead technology transfer to internal sites and CMOs/CDMOs, review manufacturing documentation, and support engineering, clinical, and GMP batches. Oversee execution and resolve technical issues, deviations, and process risks. · CMC Strategy and Cross-Functional Leadership : Serve as the Drug Product CMC representative, shaping program strategy, development plans, milestones, and risk management. Align cross-functional teams and drive timely, evidence-based decisions. · Regulatory Strategy and Technical Documentation : Author and review technical documents and CMC content for regulatory submissions. Develop scientific rationales, respond to information requests, and support health authority interactions. · Data Interpretation and Decision Leadership : Integrate experimental and manufacturing data into clear recommendations for formulation, process, clinical supply, and CMC decisions. Build evidence packages for internal governance and regulatory review. · External Partnership, Scientific Leadership, and Capability Building : Direct external partners, align scope and timelines, and resolve scientific and operational issues. Communicate findings, mentor scientists, and strengthen technical capabilities and project delivery. Education & Experience Requirements • Education : BS, MS, or PhD in Biochemistry, Chemistry, Chemical/Biochemical Engineering, Immunology, Pharmaceutics or related fields of study. • Experience : • BS: 10+ years; MS: 7+ years; PhD: 5+ years of experience in biopharmaceuti