Jobs / United States / Abbvie INC
Senior Scientist II, Biotransformation and Disposition
Abbvie INC · 🇺🇸 North Chicago, IL, US
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 177 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 94 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Abbvie INC paid sponsored hires in similar roles11 certified filings for “Senior Scientist II” (Chemists) in IL: $131k–$135k, median $134k. Most were filed at wage level IV (100%) — 4 lottery entries, ≈61% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
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Sponsor Radar — Abbvie INC
The US Department of Labor certified 177 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 94 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Abbvie INC →
About the role
The Biotransformation and Disposition team within AbbVie’s Quantitative Translational and ADME Sciences organization is seeking a driven Senior Scientist II to support AbbVie’s drug discovery and development programs through the design, execution, interpretation, and communication of in vitro and in vivo biotransformation and ADME studies. The successful candidate will apply expertise in drug metabolism, metabolite profiling, mass spectrometry, liquid chromatography, and structure elucidation to answer key scientific questions, guide project strategy, and advance compounds across the pipeline. This role requires strong scientific judgment, hands-on laboratory capabilities, cross-functional collaboration, and the ability to translate complex analytical data into clear conclusions for project teams, management, and regulatory submissions. Duties will be focused on laboratory work, and the applicant will collaborate across various disciplines within AbbVie. Additional expertise in peptide chemistry, structural elucidation, and mass spectrometry is preferred. Key responsibilities and desired skills include: • Design, conduct, interpret, and report in vitro and in vivo biotransformation studies to identify metabolites, metabolic pathways, and clearance mechanisms. • Perform metabolite profiling and structural elucidation using LC-MS/MS, high-resolution mass spectrometry, and complementary analytical techniques. • Develop, optimize, maintain, and troubleshoot chromatographic and mass spectrometric methods, including assays involving radiolabeled compounds where applicable. • Integrate metabolite data with broader DMPK, ADME, pharmacokinetic, toxicology, chemistry, and clinical findings to support compound selection and development decisions. • Represent Biotransformation and Disposition on cross-functional project teams and communicate scientific findings through presentations, technical reports, publications, and regulatory documents. • Evaluate and implement emerging technologies, study designs, automation approaches, and analytical methods to improve data quality, sensitivity, throughput, and scientific impact. • Collaborate effectively with internal and external partners while maintaining rigorous documentation, data integrity, regulatory compliance, and laboratory safety standards. • Contribute to a collaborative learning environment by mentoring colleagues, sharing technical expertise, encouraging innovation, and supporting continuous improvement. Additional preferred skills: • Design and interpret peptide biotransformation experiments to identify enzymatic cleavage sites, metabolic pathways, and structural modifications across relevant in vitro and in vivo systems. • Apply expertise in peptide mass spectrometry, including LC-MS/MS and high-resolution MS, to characterize intact peptides, metabolites, and degradation products in biotransformation studies. • Specific hands-on expertise in handling high-end high-resolution Thermo and Sciex mass spectrometers and software are desired. • Ph.D. in Chemistry, Life Sciences or a related field with 4+ years; alternatively, a Master’s degree with 8+ years or a Bachelor’s degree with 10+ years of relevant academic or industry research experience in small-molecule drug development. • Demonstrated expertise in mass spectrometry, liquid chromatography, structure elucidation, core DMPK processes, including analytical method development, metabolite profiling, and biotransformation. • Strong written (peer reviewed publications), verbal, presentation, interpersonal, and collaborative skills, with the proven ability to work independently and effectively across multidisciplinary teams. • Proven leadership capabilities, including mentoring others, fostering a learning environment, driv