Director, Clinical Pharmacology

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About the role

About Relation Relation is a sector defining TechBio company developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure. We are scaling rapidly and building a team of exceptional individuals to push the boundaries of drug discovery. You will work in highly interdisciplinary teams where biology, computation, and engineering come together to solve complex problems that have not been solved before. Our state-of-the-art wet and dry labs in the heart of London are designed to accelerate this integration and translate insight into impact. We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the basis of gender, sexual orientation, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age. By joining Relation, you will help define how medicines are discovered and deliver meaningful impact for patients. The opportunity Relation is offering an outstanding opportunity for a Director Clinical Pharmacology to help drive our growing discovery and development portfolio. This role will power translation, continuously improve the accuracy of predictions and accelerate the development of novel medicines. You will work across Translational Safety, in vivo Pharmacology and Biomarkers to drive end-to-end asset development across the entire value chain — from target assessment through to clinical support — continuously improving predictive accuracy and optimising dosing strategies for the target patient populations. Sitting within Relation's Drug Discovery team, this position is deeply embedded within cross-functional matrix project teams and will support multiple disease areas as our portfolio grows. In this position, you will play a critical role in the scientific advancement of nonclinical and clinical programmes by serving as the core quantitative and clinical pharmacology lead within project teams. You will drive all aspects of clinical pharmacology across all development phases and strategically apply Model-Informed Drug Development (MIDD) approaches to understand and translate non-clinical PK/PD into human drug development strategies, optimise trial design, justify dose selections, inform development decisions and mitigate risk across early and late-stage development. Your scope will be modality-agnostic, giving you oversight that spans small molecules, large molecules, and novel platforms. The role is a hybrid role based at our state-of-the-art facility in the heart of London. Day to day, you will • Build and own the clinical pharmacology and pharmacometric capability to support Relation's product development goals, setting standards for excellence and championing innovative approaches to drive data-informed decisions. • Act as the Clinical Pharmacology lead for multiple concurrent programmes across indications and therapeutic modalities. Oversee clinical pharmacology input into study design across the full range of development, with an initial focus on IND-enabling and dedicated Phase 1 clinical pharmacology trials, eventually leading into Phase 2 and 3 trials. • Work across Translational Safety, Translational Pharmacology and Biomarkers to integrate nonclinical and clinical data, continuously improving predictive accuracy. • Lead modelling and simulation approaches, non-clinical to clinical PK/PD, DDI risk assessment, PBPK, population PK/PD and QSP approaches to characterise d

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