Scientist I - Computational Biology, Systems Immunology

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About the role

AbbVie Immunology is expanding its early discovery Systems Immunology team in Cambridge, Massachusetts. The team is focused on identifying and evaluating new targets for the treatment of autoimmune and chronic inflammatory diseases through computational analysis of human disease tissue-derived datasets and validation using humanized experimental approaches.  We are seeking a highly motivated and skilled individual to join our team as a Computational Biology Scientist. The successful candidate will develop and apply computational approaches across single-cell, bulk transcriptomic, proteomic, and other multi-omics datasets to generate insights into disease biology, identify and prioritize therapeutic targets, and support translational research.  The individual will work in a multidisciplinary team analyzing human disease datasets, including single-cell RNA-seq, CITE-seq, bulk RNA-seq, Olink proteomics, and other molecular profiling data. The candidate will collaborate with disease-area and experimental teams to translate complex biological data into actionable target and biomarker hypotheses, and will contribute to scientific presentations, internal reports, and publications.  This position will be based in Cambridge, Massachusetts, with a hybrid work arrangement, and requires scientific curiosity, attention to detail, hands-on computational experience, and a collaborative work style.  Key Responsibilities: Single-Cell and Tissue Atlas Analysis  • Establish and apply analysis strategies for single-cell RNA-seq and CITE-seq datasets, including quality control, integration, clustering, cell-type and cell-state annotation, and differential expression.  • Build, curate, and analyze large single-cell atlases and internal patient cohorts derived from human disease tissues.  • Benchmark integration and representation-learning methods, including variational autoencoders, generative models, and foundation-model approaches.  • Use single-cell data to identify disease-associated cell states, pathways, biomarkers, and context-specific target biology.  Bulk RNA-seq and Olink Proteomics  • Develop and execute analysis workflows for bulk RNA-seq data, including quality control, normalization, differential expression, pathway enrichment, and cross-cohort comparison.  • Analyze Olink proteomics datasets to identify disease-associated proteins, biomarkers, pharmacodynamic signals, and target-related molecular signatures.  • Integrate bulk RNA-seq and Olink results with single-cell and other molecular datasets to connect tissue-level signals with relevant cell types and biological pathways.  • Collaborate with experimental and translational scientists to interpret transcriptomic and proteomic findings and define follow-up analyses.  Machine Learning and Quantitative Analysis  • Apply statistical and machine-learning methods to high-dimensional biological datasets and evaluate model performance using fit-for-purpose validation strategies.  • Use cloud and high-performance computing environments to support scalable analysis of large datasets.  Scientific Communication and Collaboration  • Interpret findings and communicate scientific data, analytical limitations, and recommendations clearly to multidisciplinary internal stakeholders.  • Present work to disease-area experts and collaborate closely with computational, translational, and experimental scientists.  • Provide computational expertise for internal and external collaborations and contribute to conference presentations, publications, and other scientific deliverables, as appropriate.  • BS or MS degree in computational biology, bioinformatics, genomics, biostatistics, computer science, or a related quantitative field, with typically 2–4 years (MS) or 5–6 years (BS) of relevant re

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