Jobs / United States / Astrazeneca Pharmaceuticals Lp
Calibration Lead
Astrazeneca Pharmaceuticals Lp · 🇺🇸 US – Tarzana – CA
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
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Sponsor Radar — Astrazeneca Pharmaceuticals Lp
The US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Astrazeneca Pharmaceuticals Lp →
About the role
The Calibration Lead will be responsible for leading calibration programs, solving instrumentation and equipment issues, developing scientifically justified tolerances, operating ranges, and acceptance criteria, and ensuring that calibration activities comply with GMP, data integrity, safety, and quality requirements. The role will work closely with Manufacturing, Engineering, Quality Assurance, Validation, Automation, Facilities, and Laboratory teams to support reliable and compliant Cell Therapy operations. Key Responsibilities • Develop and maintain risk-based calibration program for GMP equipment and instrumentation. • Lead calibration, qualification, and validation activities for critical systems and process equipment. • Troubleshoot calibration failures, instrument drift, repeat failures, and out-of-tolerance results. • Perform technical impact assessments for calibration deviations and support investigations and CAPAs. • Develop and justify calibration tolerances, operating ranges, alert limits, action limits, and acceptance criteria. • Use equipment specifications, process requirements, historical data, measurement uncertainty, and risk assessments to establish appropriate limits. • Review calibration trends and identify opportunities to optimise calibration frequencies and preventive maintenance. • Prepare and review calibration procedures, protocols, reports, certificates, and technical documentation. • Support equipment introduction, qualification, change controls, technology transfers, and decommissioning activities. • Coordinate internal technicians and external calibration service providers. • Ensure calibration activities are completed safely, accurately, on time, and in accordance with approved procedures. • Maintain compliance with GMP, Good Documentation Practices, data integrity, and site quality procedures. • Provide technical support during internal audits, regulatory inspections, and client audits. • Collaborate with Manufacturing, Engineering, Quality Assurance, Validation, Automation, Facilities, and Laboratory teams. • Promote continuous improvement, right-first-time execution, and reliable equipment performance. Required Qualifications • Degree or equivalent qualifications in Instrumentation, Electrical or Mechanical Engineering, Metrology, Automation, Biotechnology, or a related discipline. • Minimum of five (5) years’ relevant work experience in calibration, metrology, instrumentation, validation, or maintenance within a GMP pharmaceutical, biotechnology, biologics, or Cell Therapy environment. • Demonstrated experience troubleshooting complex instrumentation and equipment issues. • Experience developing and reviewing tolerances, calibration ranges, acceptance criteria, alert limits, and action limits. • Knowledge of measurement uncertainty, equipment criticality, and risk-based calibration. • Experience with deviation investigations, CAPA, change control, qualification, and validation. • Working knowledge of GMP, data integrity, Good Documentation Practices, and audit requirements. • • Experience with temperature, pressure, humidity, flow, level, mass, pH, conductivity, dissolved oxygen, gas concentration, speed, and environmental monitoring instruments. • Statistical trending, calibration interval optimization, and measurement uncertainty calculations. Desired : • Experience with calibration or maintenance management systems is desirable. • Familiarity with EU GMP, FDA GMP, ISO/IEC 17025, and applicable metrology standards is a plus. Core Competencies • Strong technical troubleshooting and root-cause analysis skills. • Ability to make sound, science- and risk-based decisions. • Strong understanding of GMP and data integrity requirements. • Effective communication