Jobs / United States / Altos Labs INC
Scientist / Senior Scientist, Membrane Biochemistry
Altos Labs INC · 🇺🇸 San Francisco Bay Area, CA
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 10 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 1 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Altos Labs INC paid sponsored hires in similar roles8 certified filings for “Scientist II, Biological Sciences” (Molecular and Cellular Biologists) in CA: $127k–$148k, median $141k. Most were filed at wage level III (75%) — 3 lottery entries, ≈46% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
Or apply yourself on the official page →
Sponsor Radar — Altos Labs INC
The US Department of Labor certified 10 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 1 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Altos Labs INC →
About the role
Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at altoslabs.com. Our Value Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission . Diversity at Altos Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos As an individual contributor and Scientist in Discovery Science, you will advance Altos' scientific programs on brain aging and neurodegeneration using lipid and protein biochemistry approaches. The ideal candidate is an expert in membrane and lipid biology with experience purifying and structurally characterizing transmembrane or peripheral membrane-binding proteins. You will design and implement workflows that include construct design, expression and purification from mammalian recombinant sources, chromatography purification, membrane reconstitution, and vitrification for electron microscopy. You will also carry out biochemical activity assays and characterize biophysical properties of purified proteins, including hydrodynamic radius, binding kinetics, protein stability, and oligomerization. Experience with mass spectrometry, NMR, or X-ray crystallography of lipid-protein interactions is also of interest but not required. This position is in the Frost group at Altos Labs' Bay Area campus. Responsibilities • Design expression constructs and perform recombinant cell culture for membrane protein and membrane-associated protein purification and characterization. • Evaluate the purity, stability, and physical properties of purified proteins. • Develop new protein activity assays and establish SOPs. • Coordinate with CROs for material generation and analysis. Who You Are Minimum qualifications • PhD in a related field, such as Biochemistry, Chemistry, Biophysics, or Structural Biology • Demonstrable understanding of biochemistry, including the use of electron microscopy for structural biochemistry. • Excellent communication skills and proven ability to collaborate within a dynamic team. • Demonstrated experience with quantitative binding biophysics (BLI, SPR, or ITC), including kinetic and affinity analysis. • Experience with methods for assessing purity, mass, or stability (mass photometry, SEC-MALS, DLS, analytical SEC, or DSF/thermal stability). • Experience reconstituting membrane or lipid-associated proteins into liposomes or nanodiscs. • Experience with Cryo-EM sample preparation and data analysis workflows. • High level of rigor and precision in experimental design, data recording, and documentation in an ELN. • A proactive, problem-solving attitude with the ability to independently troubleshoot, manage multiple priorities, and deliver under timelines. Preferred qualifications • Experience with AI-assisted protein design pipelines. • Immunoassay development (ECL/MSD, ELISA). • Bioconjugation or synthetic chemistry for lipid, glycan, or fluorophore probes. The salary range for Redwood City, CA • Scientist I, Scientific Technologies: $136,300 - $174,700 • Scientist II, Scientific Technologies: $156,800 - $201,000 • Senior Scientist I, Scientific Technologies: $172,400 - $221,000 Exact compensation may vary based on skills, experience, and location. #LI-NN1 For UK applicants, before submitting