Senior Associate Scientist, Cellular Analytical Development

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About the role

Company Overview: Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety. Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA. Become the next standout single strand! Job Summary: Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company. We are looking for a highly motivated and innovative candidate for the role of Senior Associate Scientist of Cellular Analytical Development. The expectation is that the Senior Associate Scientist will have experience independently executing cell-based experiments using various cell and molecular biology techniques. Reporting to the Scientist of Cellular Analytical Development, the right candidate will be a strategic thinker that brings a leadership presence and enthusiasm for Strand along with a desire to conquer new challenges. Primary Responsibilities: • Responsible for running and developing cell-based mRNA and LNP analytical methods. • Assist in transfer of cell-based methods to external collaborators. • Use various statistical tools to analyze and independently draw conclusions about data. • Analytically support screening, optimization, and scale-up efforts in mRNA and LNP Process Development. Qualifications: • B.S. or advanced degree in Biology, Biochemistry, Molecular Biology, Chemistry, Chemical Engineering or other relevant scientific discipline. • 3+ years of experience with a focus on cell-based assays and their various readouts (ELISA, PCR, flow cytometry etc.) required. • Experience with mammalian or ex-vivo tissue culture required. • Understanding of enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for biologics or nucleic acid therapies • Background in or experience with one or more of the following would be strong pluses: • Flow cytometry-based assay development • T cells and other primary cell culture • Immunology • Late clinical stage cell-based potency assays • Benchling template making and data handling • Automation • This position requires conducting laboratory experiments, excellent documentation review and writing skills, and the flexibility to work on multiple projects as needed • Familiarity with process development, and/or regulatory aspects of mRNA-(lipid) nano

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