Jobs / United States / Harvard University
Scientist II
Harvard University · 🇺🇸 Boston, MA, US
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 123 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 73 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Harvard University paid sponsored hires in similar roles1 certified filing for “Senior Research Scientist” (Health Education Specialists) in MA: $180k–$180k, median $180k. Most were filed at wage level IV (100%) — 4 lottery entries, ≈61% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
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Sponsor Radar — Harvard University
The US Department of Labor certified 123 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 73 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Harvard University →
About the role
About the Role: We are looking for a talented scientist to lead the development and characterization of our antibody brain shuttle compounds and to optimize our shuttles for specific payloads in neurodegenerative diseases. Reporting to the Principal Scientist, you will work closely with our team, Brain Targeting Program (BTP), using both in vitro cellular systems and in vivo humanized mouse models. You will determine brain PK/PD profiles of our shuttle compounds, their biophysical properties, and assess therapeutic applications. The mission of the Wyss BTP is to develop a robust modular brain delivery platform that is able to deliver large-molecule therapeutics for diverse brain diseases. We aim to help expand the pipeline of CNS drugs by making our platform broadly available to companies, academics and non-profit organizations. About You: You are a collaborative, impact-focused problem solver who wants to be part of a dynamic team dedicated to creating and commercializing novel approaches to global challenges in healthcare and sustainability. You want the freedom to explore, to push the boundaries of what is possible, and to use your ambition to tackle challenging projects in a fast-paced, industry-focused environment without a lot of administrative hurdles. You enjoy working with diverse groups of people and leveraging your expertise to create innovations that can change the world. What you'll do: • Independently develop, validate, and perform various protocols including confocal microscopy, flow cytometry, cell-based assays, plate-based ELISA assays, and others • Present data and results at internal and external meetings; Mentor and train less experienced technicians, academic trainees, and others • Lead vitro and in vivo validation of antibody shuttles, using protein and cell binding assays, and in vivo brain and blood pharmacokinetics and pharmacodynamic (PK/PD) studies in mouse models; • In vivo procedures include tail-vein intravenous injection, tissue (brain, blood and peripheral tissues) harvesting and lysate preparation; • Perform ELISAs using various types of samples; analyze and summarize data timely and accurately; • Conduct biophysical characterization of antibodies, including but not limited to affinity determination with SPR, BLI, and stability and purity assessment • Lead one or more projects to engineer and optimize shuttles for specific therapeutic payloads to treat brain diseases. • Perform support activities and lab maintenance as assigned, and function in a team-oriented environment with other scientists and staff at the Institute, as well as with external collaborators. What you'll need: • Bachelor’s degree neuroscience, biology, molecular biology, biochemistry, or related field. • A minimum of 5 years of experience with cell culture, rodent handling, protein/antibody analytics, and molecular and cellular biology techniques such as ELISA, western blotting, confocal imaging, fluorescence-activated cell sorting (FACS), or related experience. Advanced education may count towards years of experience. Desirable skills: • PhD strongly preferred in neuroscience, biology, molecular biology, biochemistry or related field. • Industry experience preferred. • Experience with protein science and analytics, including experience with BLI, SPR, SEC and others. • Ability to work independently as well as to collaborate with a multidisciplinary, diverse group of scientists and allied personnel. • Standard Hours/Schedule: 35 hours per week • Visa Sponsorship Information: Harvard University is unable to provide visa sponsorship for this position • Pre-Employment Screening: Identity, Education, Criminal, Occupational Health Screening. Why you’ll like working with us: At the Wyss Institute, you’re a membe