Senior IT Systems Analyst, G&A

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: Sr. IT Systems Analyst, G&A is responsible for leading the architecture, design, and evolution of G&A platforms, with a strong focus on scalable process design and cross-system integration. This role partners with HR, IT and other G&A teams to implement and support end-to-end business processes, establish architectural standards, and contribute to technology decisions that enable efficiency and growth. The analyst ensures platform reliability, data integrity, and seamless operations while delivering strategic enhancements and managing system releases in alignment with organizational priorities. This is a hands-on role that reports to the Associate Director of Enterprise IT Systems at Vaxcyte’s San Carlos, California headquarters. Essential Functions: • Serve as an IT point of contact for G&A stakeholders; gather, analyze, and document business needs for processes and systems. • Document current-state and future-state processes; translate business needs into functional requirements, and system specifications. • Support governance and compliance controls (e.g., SOX ITGC where applicable), including access reviews, role/permission audits, segregation of duties considerations, and evidence documentation. • Support recurring reporting cycles and audit requests by ensuring data quality, traceability, and timely delivery of requested information. • Drive SDLC standards and best practices for technology delivery (intake, requirements, design, testing, release, and documentation) to improve consistency, quality, and auditability. • Facilitate communication between HR, IT, other G&A teams and implementation partners to align on scope, priorities, timelines, and outcomes. • Support implementation of new features and releases, including test planning, test script creation, UAT coordination, regression testing, rollout planning, and post-go-live stabilization. • Develop and maintain support materials, training content, job aids, and end-user documentation to drive adoption and consistent process execution. • Ensure G&A systems are operated in accordance with IT policies and procedures, privacy/security expectations, and applicable regulatory requirements. • Manage governance for change management across the responsible G&A ecosystem (e.g., change intake and prioritization, change calendar, risk/impact assessment, approvals/CAB as applicable, communications, and release readiness). • Develop and maintain documentation (requirements, process flows, training, end-user guides) a