Senior Scientist, Cell Therapy

Senior Scientist, Cell Therapy Introduction to role Are you ready to turn cutting-edge cell engineering into therapies that reshape how cancer is treated? As a Senior Scientist, Cell Therapy based in Gaithersburg, MD, you will drive critical product and process characterization that informs design decisions, accelerates candidates to the clinic, and ultimately impacts patients who need new options most. You will join a fast-moving, collaborative lab environment where change is constant and curiosity is expected. Do you thrive when working with unknowns, translating complex datasets into clear direction, and partnering across disciplines to move science forward with pace and precision? This role offers the opportunity to see your bench work translate into program strategy and clinical progress. Accountabilities • Product and process characterization: Design and execute hands-on studies that define attributes of cellular therapies and underpin robust, scalable processes. • Analytical readouts: Lead characterization of cellular products using multicolor flow cytometry, ELISA, dPCR, karyotyping, microscopy, biomarker and cytokine analyses, and -omics approaches to generate decision-ready data. • Data translation and communication: Assess, synthesize, and report findings with clarity and urgency; ensure insights are relayed efficiently for forward translation into program plans. • Experimental design and troubleshooting: Independently plan, optimize, and troubleshoot experiments to meet milestones and de-risk development. • Cross-functional collaboration: Partner closely with project managers and adjacent teams to align assay strategy, timelines, and deliverables with program needs. • Scientific impact in drug discovery: Interpret results within the broader mechanism and development context to shape next experiments and guide program direction. • Documentation and quality: Maintain rigorous records and high data integrity to support quality, compliance, and reproducibility. Essential Skills/Experience • PhD in a relevant subject area with 0-3 years of demonstrated experience in Cellular Therapy, Cell Biology, Cell engineering, Bioinformatics, Immunology, and/ or Immuno-Oncology; M.S. with 5+ years’ experience; B.S. with 10+ years’ experience • Extensive in vitro skillset for cell characterization such as functional/potency assays, morphological/phenotypic assessment, and sequencing based methods. • Multicolor flow cytometry, microscopy, biomarker and cytokine analysis, ELISA, dPCR, karyotype and -omics. • Experience analyzing large process and characterization data sets using a breadth of statistical methods including machine learning algorithms. • Well-developed understanding of molecular and cellular biology (specifically immune cell physiology), immunological assays, and cell transfection/transduction. • Proficiency in cell culture and aseptic techniques. • Ability to design, execute, troubleshoot, and document experiments; to review, analyze, interpret results; and communicate deliverables in a timely manner. Desirable Skills/Experience • Experience with genome editing technologies (CRISPR/Cas9, base-editing, virus-based genetic delivery systems, etc.). • In vitro experience isolating and culturing human T cells. • Basic experience developing cellular therapies including CAR-T therapies. • Proficiency with statistical software (JMP, R, etc.). • Working cross-functionally to drive project advancement. Why AstraZeneca Here, bold science meets practical impact: you will work in modern labs alongside immunologists, bioengineers, data scientists, and manufacturing experts—often in the same room—sparking ideas that move from bench to clinic with speed. We embrace ambiguity, take calculated risks, and learn fast, b