Annotation Analyst, Laboratory Medicine

Union: Non-Union Number of Vacancies: 1 New or Replacement:  New Site: All Sites Department: Laboratory Medicine Program, Advanced Diagnostics Reports to: Senior Manager, Advanced Diagnostics Hours: 37.5 hours per week Salary:  $37.85 to $56.77 per hour   Shifts: All Shifts 24/7 Status:  Permanent Full Time Closing Date: October 21, 2026 Position Summary Join UHN's Laboratory Medicine Program, Canada's largest hospital diagnostic lab and a global leader in academic labs. With over 30 million tests per year and 1,300 outpatients served daily, we are at the forefront of pathology and clinical testing. Embrace innovation and contribute to ground-breaking research, education, and exemplary service. Join our dynamic team of 700 dedicated staff and play a pivotal role in shaping the future of laboratory medicine. As an integral member of the Clinical Genomics team, the Annotation Analyst plays a key role in supporting the efforts of the Clinical Genome Diagnostics laboratory. Duties • Utilizing software tools, databases and primary literature to investigate the clinical relevance of variants detected by genetic methods including next-generation sequencing (NGS) • Drafting concise variant interpretations • Utilizing practical and theoretical knowledge for the analysis of NGS and other laboratory data, including somatic and germline testing • Completing required database and reporting activities related to variant analyses • Completing assigned workload in a manner to ensure the efficient operation of the clinical laboratory • Participating in molecular profiling test development activities with laboratory technologists • Maintaining quality control standards in assigned area • Participating in communication activities to maintain and continually enhance the co-operation and coordination of services with other laboratory staff and with external lab clients • Participating in professional development, teaching/education activities, safety and quality improvement programs to ensure excellence in the provision of services • Adhering to Hospital and departmental mission and value statements while maintaining patient confidentiality • Master's degree in Molecular Genetics or related discipline required at minimum • 6 months minimum of relevant experience required • Knowledge of and experience with molecular genetic variant assessment techniques  • Knowledge of and experience with the use of genetic databases / resources and software (e.g. HGMD, COSMIC, gnomAD, cBioPortal, CICiC, ClinVar) • Knowledge of and experience with the theory and application of NGS platforms and NGS analysis • Knowledge of the theory and practice of current NGS laboratory procedures, instruments, equipment and special techniques • Excellent problem recognition and problem solving skills • Effective organizational, time management and prioritization skills • Excellent verbal and written communication skills • Ability to learn quickly, take in and distill large amounts of information and apply scientific knowledge • Scientific curiosity and interest to stay on top of emerging scientific data and trends as it pertains to the role • Demonstrated ability to take initiative, multitask and think critically • Ability to work independently and with cross-functional team members Why join UHN? In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN. • Competitive offer packages • Government organization and a member of the Healthcare of Ontario Pension Pl