Associate Director, Business Operations & Digital Enablement

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: This role within Technical Operations’ Commercialization Capabilities and Strategic Projects function is critical for building and strengthening the business operations, data, digital tools, and performance insights that help Technical Operations leaders make better decisions, allocate resources effectively, anticipate risks, and execute with greater clarity as the organization advances toward commercialization and future growth. This role creates an integrated view of Technical Operations priorities, capacity, risks, dependencies, progress, and performance, while identifying opportunities to simplify and automate how the organization works. Working across Technical Operations and with teams across Vaxcyte, this role will translate business needs into practical, scalable solutions that improve visibility, decision-making, and organizational performance. The successful candidate combines strong business judgment with analytical, systems, and digital fluency. This is not simply a reporting or technology role; it calls for someone who understands how the business operates, can turn data into actionable insight, and can apply systems, automation, analytics, and AI to strengthen the organization’s ability to scale. Essential Functions: Business Operations & Portfolio Management: • Build and continuously improve business operating practices that give leaders an integrated view of Technical Operations priorities, initiatives, capacity, risks, dependencies, milestones, and performance. • Establish and support portfolio and capacity-management processes that enable proactive prioritization, resource tradeoffs, and leadership decisions. • Support demand intake, strategy realization, and execution-readiness processes with business analysis, data, and decision support. • Partner with leaders to identify resource constraints, emerging risks, cross-functional dependencies, and opportunities that need leadership attention. • Develop scalable operating rhythms and business review mechanisms that connect strategy, portfolio performance, and organizational decision-making. Performance Insights & Decision Support: • Develop executive dashboards, KPIs, reporting, and operational insights that improve visibility and enable timely, data-informed decisions. • Create shared visibility into priorities, risks, progress, improvement efforts, and performance where transparency improves execution. • Translate complex operational data into clear insights, scenarios, tradeoffs, and recommend