Scientist I, Oncology

The Role: Generate:Biomedicines is seeking a Scientist I with expertise in cancer biology to support the discovery and development of protein-based oncology therapeutics. As a member of a multidisciplinary team, this individual will plan and execute cellular assays, interpret results, and generate reproducible data that inform project decisions. This highly laboratory-focused role requires sound scientific judgment, rigorous documentation, and effective collaboration. The core focus will be oncology, with opportunities for a curious scientist to expand their drug discovery and development experience across other therapeutic areas as project needs evolve. Here's how you will contribute: • Establish, maintain, and characterize cancer cell lines, tumor organoids, and primary cells, including cells from primary human tumor samples, to support target validation and therapeutic evaluation. • Generate and validate engineered cell lines using approaches such as transfection, transduction, and CRISPR-based editing to modulate target expression or introduce assay reporters. • Design, execute, and troubleshoot assays of cell viability, proliferation, cytotoxicity, target binding, and receptor or antibody internalization, including tumor and immune cell co-cultures where appropriate. • Apply flow cytometry, live-cell imaging, plate-based assays, and immunoassays such as ELISA, AlphaLISA, and Meso Scale Discovery (MSD), together with molecular biology and biochemistry techniques, to characterize therapeutic activity and mechanism of action. • Analyze, interpret, and present experimental findings, recommending next steps that support project decisions and pipeline progression. • Collaborate with cross-functional partners in Automation, Computational Sciences, Protein Sciences, and High-Throughput Screening to advance shared project goals. • Maintain complete and accurate experimental records and stay current with relevant advances in oncology, immuno-oncology, and biologics research. The Ideal Candidate will have: • Ph.D. in cancer biology, cell biology, immunology, immuno-oncology, or a related field; or a master’s degree in a related field with six years of relevant experience; or a bachelor’s degree in a related field with eight years of relevant experience; or eleven years of relevant experience. • Strong foundation in cancer biology and hands-on mammalian cell culture expertise, including work with cancer cell lines and primary cells. • • Hands-on experience with in vivo tumor models, such as xenograft, patient-derived xenograft (PDX), or syngeneic models, including assessment of tumor growth, treatment response, and pharmacodynamic biomarkers. • Experience with cell line engineering and standard molecular biology and biochemistry techniques, such as cloning, PCR/RT-qPCR, and Western blotting. • Experience developing and troubleshooting quantitative cell-based assays, including cytotoxicity, viability, or internalization assays. • Proficiency in flow cytometry and experience measuring proteins or cytokines using platforms such as ELISA, AlphaLISA, or MSD. • Ability to independently plan experiments, select appropriate controls, analyze and interpret quantitative data, and recommend follow-up studies. • Experience communicating scientific findings and collaborating within a multidisciplinary project team. Preferred Qualifications: • Experience with tumor organoids, primary human tumor samples, or other patient-derived ex vivo models. • Experience characterizing antibodies, multispecific proteins, or antibody conjugates in oncology, ideally in an industry setting. • Experience with tumor and immune cell co-cultures, high-content or live-cell imaging, high-throughput screening, or machine learning-enabled drug discovery