Vice President, Program Leadership (Launch Products)

MISSION Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously. POSITION SUMMARY The VP, Program Leadership (Launch Products) is accountable for defining and driving the global strategy to maximize the long-term value of Mirum’s late-stage products. The Program Leader leads a cross-functional team spanning U.S. and International Commercial, Development, Regulatory, Medical Affairs, CMC/Technical Operations, Market Access, Finance, and other functions, ensuring alignment around a single integrated product vision and strategy. The VP, Program Leadership (Launch Products) will initially provide leadership across Mirum’s commercial-stage portfolio, including LIVMARLI, ATEBRIOZ, CHOLBAM, and CTEXLI, identifying and prioritizing opportunities to maximize patient impact and product value globally. The Program Leader operates as “Program CEO,” leading product strategy and execution, influencing executive leadership, and bringing together cross-functional leaders around a shared vision JOB FUNCTIONS/RESPONSIBILITIES Global Product Strategy and Value Maximization for Commercial Portfolio • Define and execute the integrated global lifecycle strategy for assigned products, establishing the long-term vision and value-maximization plan, taking into account risks, tradeoffs, and value • Identify and prioritize opportunities across geographies, indications, patient segments, formulations, evidence generation, regulatory pathways, and other lifecycle initiatives. • Continuously reassess product strategy based on emerging clinical data, competitive developments, market dynamics, regulatory changes, product performance, and IP considerations. • Lead the cross-functional Program Team, including representatives from U.S. and International Commercial, Development, Regulatory, Medical Affairs, CMC/Technical Operations, Market Access, Finance, Legal, and other relevant functions. • Working closely with regional commercial leaders, evaluate geographic expansion opportunities and commercialization models, including direct entry, distributors, partnerships, and licensing. • Lead the evaluation of new indications, expanded patient populations, label enhancements, combination strategies, and other development opportunities • Drive cross-functional decision-making, ensuring key trade-offs and internal resource constraints are identified, evaluated, and resolved. • Working closely with Finance and other cross-functional leaders, rationalize, get endorsement, and manage the Program Team budget, as part of the annual long-range planning exercise Success Criteria The successful Program Leader will: • Lead through influence across senior cross-functional stakeholders and create accountability across organizational boundaries. • Balance commercial opportunity with scientific, regulatory, operational, and financial considerations, making explicit strategic choices and trade-offs. • Prioritize lifecycle opportunities and investments based on patient impact, strategic fit, value creation, probability of success, investment requirements, and organizational capacity. • Develop and communicate business cases, investment recommendations, and strategic scenarios to executive leadership and governance committees to drive timely decisions and resource allocation. • Translate complex information into clear recommendations and decisions. • Maintain a global, long-term perspective while driving