Vice President, Translational Development

About Stoke: Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/ Position Overview We are seeking a dynamic, experienced Head of Translational Development to lead the strategy connecting preclinical research with clinical development across a growing portfolio of RNA based therapeutics. This individual will oversee clinical pharmacology, pharmacokinetics, translational biomarkers, regulated bioanalysis, and antidrug antibody assessment. The successful candidate will bring deep expertise in translating preclinical data into clinical development strategies, informing dose selection, establishing exposure response relationships, and generating evidence to support clinical and regulatory decision making. The portfolio includes clinical-stage assets in rare central nervous system indications. The ideal candidate combines broad scientific expertise and industry perspective with strong organizational leadership and the ability to communicate effectively with executive leadership, regulatory authorities, and cross functional teams. This leader will partner closely with research, nonclinical development, clinical development, regulatory affairs, biostatistics, CMC, and program management. The ideal candidate combines scientific depth with strategic leadership and can guide programs from preclinical development through clinical execution and regulatory submission. As a senior R&D leader, this individual will lead and develop the translational development team, help shape R&D priorities and broader corporate strategy, and champion novel translational science. Key Responsibilities • Establish and lead an integrated translational development strategy across preclinical and clinical stage programs. • Establish vision and provide strategic and organizational enterprise leadership across the translational team, including clinical pharmacology, pharmacokinetics, translational biomarkers, regulated bioanalysis, and immunogenicity assessment. • Serve as the senior translational development and clinical pharmacology expert for cross functional program teams and executive leadership. • Communicate the translational medicine strategy, program risks, and development recommendations clearly to executive leadership and other key stakeholders, including presentations to the executive leadership team and Board of Directors. • Contribute translational development perspectives to R&D priorities, portfolio decisions, and broader corporate strategy. • Translate clinical pharmacology, toxicology, DMPK, biomarker, and bioanalytical findings into clinical development strategies. • Develop clinical starting dose, dose escalation, dose optimization, and regimen selection strategies. • Lead pharmacokinetic, pharmacodynamic, exposure response, and population pharmacokinetic analyses. • Integrate clinical pharmacology and translational data to support patien