Jobs / United States / Astrazeneca Pharmaceuticals Lp
Senior Director, Site Manufacturing Science and Technology, Cell Therapy Technical Operations
Astrazeneca Pharmaceuticals Lp · 🇺🇸 US - Gaithersburg - MD
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Astrazeneca Pharmaceuticals Lp paid sponsored hires in similar roles2 certified filings for “Statistical Science Associate Director” (Statisticians) in DE: $205k–$209k, median $207k. Most were filed at wage level I (50%) — 1 lottery entry, ≈15% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
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Sponsor Radar — Astrazeneca Pharmaceuticals Lp
The US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Astrazeneca Pharmaceuticals Lp →
About the role
AstraZeneca is seeking a Senior Director of Manufacturing Science and Technolog y ( MSAT ) to serve as senior- technical leader for the Cell Therapy manufacturing sites across a global network of AstraZeneca . You will be responsible for receiving manufacturing process at the sites and supporting clinical manufacture, process validation and commercial manufacture at AstraZeneca’s internal manufacturing sites, partnering closely with Manufacturing Operations, Quality, Supply chain and QC Operations teams located at the manufacturing sites. This is a leadership position responsible for developing and managing MSAT teams located at the manufacturing sites. Your group will own the cell therapy manufacturing support for the sites — from tech transfer of the clinical manufactur ing process to the process validation, commercial manufacture , and post-approval process improvements specific to manufacturing sites — partnering with Global Manufacturing Science and Technolog y and Manufacturing Operations team s. Responsibilities Team Leadership & Strategy • Define and execute the Site MSAT function strategy aligned with Cel l Therapy Technical Operations to enable development and supply objectives across clinical and commercial stages. • Build, mentor, and develop a high -performing Site MSAT team s with deep expertise in cell therapy GMP operations and process science and technology. • Serve as a core member of the site Manufacturing Operations team , contributing to long-range supply planning, risk mitigation, and operational excellence . • Lead , develop and oversee late-stage and commercial process execution strategies at manufacturing sites to enable harmonization and quality and regulatory compliance . Development and Manufacturing Interface • Represent Site MSAT in technology transfer , process validation and commercial supply teams to ensure successful supply of cell therapy products . • Represent Manufacturing Operations in the CMC team, ensuring high-quality and timely program deliverables (clinical & commercial supply, site approvals) . • Lead Clinical manufacture and PPQ readiness at the manufacturing site that includes material, facility, equipment, manufacturing systems , documentation and process operations readiness . • I mplement and maintain Proactive Process Analysis (PPA) and Continued Process Verification (CPV) strategies across manufacturing sites to ensure continued process understanding and process control across all manufacturing sites Lifecycle Management • Identify and implement process improvements that improve process robustness, cost of goods, plant throughput , and supply continuity within the boundaries of an approved or cleared clinical products . • Proactively identify and mitigate technical and operational risks; drive lessons-learned cycles and standardization across sites and teams. Regulatory & Quality Support • Serve as the senior accountable Site MSAT leader for regulatory submissions — Pivotal IND a , BLA, MAA, and supplements — reviewing CMC sections to ensure alignment with the site operations . • Lead site preparedness and technical support for health authority inspections and audits working closely with Quality and Manufacturing Ops teams. • Partner with quality and regulatory to maintain full compliance with cGMP, ICH guidelines, and global regulatory expectations . • Develop and defend sound scientific justifications for site operations (SOP s , MBRs, Manufacturing systems, Operation training s) , and any site-specific changes to the a pproved products. • Lead site-specific Change Controls and ensure timely implementation and compliance working with global MSAT team . Cross-Functional Partnerships You will work in cl