Principal Manufacturing Systems Analyst

About the Team:   Enterprise Systems is the backbone of GSK’s internal operations in Digital & Tech, enabling GSK Global Functions teams such as Finance, Procurement, HR, Legal, Compliance, WREF, CGA and Corporate Secretariat to run seamlessly. This team designs and delivers cutting-edge digital platforms that power critical processes, ensuring efficiency, compliance, and scalability across the enterprise.     Enterprise Systems Management & Business Operations delivers digital solutions that support Enterprise Systems running as a high-performing organisation. This team drives financial discipline, operational rigour and strategic alignment across the ES portfolio that safeguard GSK’s integrity and reputation globally. By joining this team, you’ll help shape systems that support thousands of employees worldwide, driving innovation and reliability in the tools that keep GSK moving forward. Job Purpose  The Manufacturing Systems Analyst is the subject-matter expert for manufacturing systems, manufacturing processes and the data generated across shop-floor, laboratory and manufacturing-operations environments. The role develops a detailed understanding of how equipment, automation, historians, MES/MOM, LIMS/LES, PAT and related systems create, transform and consume data, and ensures that information is usable by Manufacturing, MSAT, Quality, CMC and R&D stakeholders.  The role analyses data flows across ISA-95 (International Society of Automation standard 95) Levels 2, 3 and 5 and translates manufacturing and scientific needs into clear requirements, process models, source-to-target mappings, contextualization rules, data-quality controls and acceptance criteria. The job holder works closely with FIL, automation, OT, application, data, cloud and architecture teams, providing the manufacturing-data expertise needed to design integrations and data products that preserve batch, material, asset, process, sample, method, timestamp, unit, quality and provenance context.  The role acts as the bridge between manufacturing and technical teams, supporting discovery, design, testing, deployment, issue investigation, and continuous improvement. It develops reusable manufacturing data definitions, mappings, analysis methods, documentation and training, while promoting consistent interpretation and use of manufacturing data across sites, products and programs.  Key Responsibilities  • Analyze end-to-end business processes, system interactions and data flows across ISA-95 Level 2 equipment and control systems, Level 3 manufacturing operations systems, and Level 5 enterprise, analytics, cloud and R&D platforms.  • Use approved AI tools in your day-to-day work to improve your own productivity and your team’s ways of working, sharing what works and applying sound judgement, including validating outputs and following GSK’s Responsible AI, privacy and security requirements.  • Hold mappings, interface definitions and test scenarios under version control, peer-review them before release, and run scripted data-reconciliation and regression checks with the evidence kept with the change.  • Lead functional and data investigations across manufacturing systems, escalating promptly where batch execution, product quality, patient supply, data integrity or scientific interpretation may be affected.  • Define functional interface requirements and detailed manufacturing data mappings for automation, historians, MES (Manufacturing Execution System)/MOM (Manufacturing Operations Management), LIMS (Laboratory Information Management System)/LES (Laboratory Execution System) , PAT (Process Analytical Technology), laboratory instruments, asset systems and enterprise or scientific data platforms.  • Analyze manufacturing records, events, tags, messages, logs,