Principal Scientist, Early Pipeline Development

Job Description Summary We are seeking a highly motivated Principal Scientist I with extensive AAV gene therapy manufacturing experience to develop state-of-the art downstream purification processes for next-generation AAV gene therapy.  This role is also responsible for executing early-stage process development with the focus on developability of AAV gene therapy lead candidates as well as new platform process development for existing and novel AAV capsids and cargo vectors.   Job Description Internal Job Title: Principal Scientist I/II Position Location: Onsite, San Diego, CA Key Responsibilities: • Lead and manage a 3-5 person downstream process team and provide technical support, training, and SME knowledge to assist with the professional development of direct reports. • Coordinate activities with associates across upstream process and analytical teams. • Develop strategies in collaboration with Disease Areas and partner with various line functions to support early drug discovery from target selection and validation through lead compound selection and developability assessment. • Serve as a subject matter expert to transfer manufacturing process knowledge to Technical Research & Development team and advance pipeline programs into clinical phases. • Lead effort and work collaboratively with Technical Research & Development to develop innovative and cost-effective downstream processes for next-generation AAV. • Manage multiple project workflow to ensure timely delivery. • Prepare written reports conforming to defined documentation practices including electronic lab notebook. • Other related duties as assigned. Essential Requirements: • PhD in bioprocessing, biochemical engineering, gene therapy or a related field with 3+ years of relevant process development experience in biotechnology/ pharmaceutical environment. • Experience in people management • Knowledge of downstream purification processes including affinity and ion-exchange chromatography with hands on experience with AKTA purification systems. • Technical proficiency, creativity, and independent thoughts • Effective communication skills to convey scientific concepts to research scientists and cross-functional collaborators. • Strong organization and problem-solving skills with attention to details. • Ability to work in a fast-paced and matrix environment. Desired Requirements: • Experiences in AAV gene therapy • Experience with viral gene therapy The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click here .   EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, ma