Principal Scientist, Drug Product Process Engineer

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D Job title: Principal Scientist, Drug Product Process Engineer Location : Siena, Italy Employment type: Permanent, full time Closing date for applications: 11 November 2026 Job Purpose We are seeking an experienced Principal Scientist, Drug Product Process Engineering to support sterile drug product development through process engineering, process modelling, advanced analytics, and digital technologies. In this role, you will provide technical leadership across development programs, applying scientific and engineering expertise to enhance process understanding, support scale-up and technology transfer, and deliver robust manufacturing processes. You will work within multidisciplinary teams and contribute to the adoption of innovative, data-driven approaches throughout development. This is an individual contributor role with no direct reports. Responsibilities: Scientific & Technical Leadership • Provide process engineering expertise within multidisciplinary CMC teams across development, scale-up, and commercialization activities. • Apply modelling, data analytics, and digital tools to improve process understanding, performance, and robustness. • Support sterile drug product process development, characterization, scale-up, and technology transfer across multiple modalities. • Contribute scientific insight and risk-based recommendations to support technical decision-making and project progression. • Identify and resolve technical challenges to enable successful development outcomes. Collaboration & Project Delivery • Collaborate effectively with development, manufacturing, and cross-functional teams to achieve project objectives. • Contribute to planning and execution of development activities and milestones. • Assess technical risks and recommend appropriate mitigation strategies. • Support implementation of continuous improvement, modelling, and digitalization initiatives. • Mentor junior scientists and share technical knowledge within the organization. Regulatory & Scientific Communication • Ensure compliance with applicable quality, regulatory, safety, and data integrity requirements. • Author and review technical reports, development documentation, and regulatory submissions. • Clearly communicate technical findings and recommendations to stakeholders. • Contribute to innovation through publications, presentations, patents, or invention disclosures. Why You? Basic Qualifications & Skills We are looking for professionals with these required skills to achieve our goals: • Engineering degree, Pharmaceutical Sciences, Biotechnology, or related discipline. • Relevant experience in sterile drug product development, process engineering, and technology transfer within the pharmaceutical or biotechnology industry. • Experience in process characterization, scale-up, manufacturing science, and process improvement. • Experience applying modelling, PAT, automation, analytics, or digital technologies in development or manufacturing environments. • Strong technical problem-solving, communication, and collaboration skills. • Fluent written and verbal E