Jobs / United States / Prime Medicine INC

Prime Medicine INC

Director, Program Management

Cambridge, MA Posted today

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Sponsorship verdict

Sponsorship possible

One solid signal, not two. Worth applying, and worth asking about sponsorship early.

  • Employer is on a government sponsor recordThe US Department of Labor certified 2 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jan 2026) — the step every H-1B hire needs first.
  • The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
  • No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area.
  • Confirmed live todayWhen a source last listed this job as open.
Details and sources
Employer is on a government sponsor record
The US Department of Labor certified 2 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jan 2026) — the step every H-1B hire needs first. Source: LCA disclosure data (US Department of Labor (OFLC)).
No salary bar for this route
H-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.

US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).

A verdict summarises public evidence. It is not legal advice and never a guarantee: the employer and the immigration authority decide. Sign in to factor in where you can already work.

About the role

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com . Position Overview: We’re looking for an outstanding program manager with experience advancing early discovery programs through IND approval. This leader will refine and reinforce our program management methodology and lead program management in our early research teams. This role reports to the Vice President, Programs and Strategy. Responsibilities: As a Program Manager: • Working in partnership with research team leadership to develop and guide program strategy, set program goals and facilitate team decision making for the program • Lead a range of program management activities across programs, including development of project plans, timeline and milestones tracking, team meeting management/minutes, and decision-making support • Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency • Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans • Develop and manage the program budget, and long-range plan, including scenario planning as needed, monitor program financials and resourcing plans • Facilitate strong cross-functional communication by building strong working relationships across the organization • Develop materials and present program updates/progress at internal company meetings Enhancing the Program Management function: • Responsible for the management and communication of Prime’s discovery-stage program plans • Facilitate cross-functional communication, including input to Leadership Team on program progress • Support strategic scenario planning discussions, develop risk/mitigation plans, and drive key program decisions through our governance forums • Reinforce high standards and high performing teams to advance our science • Support strategic & tactical program planning in partnership with Finance and Strategy/ Portfolio Management, to inform the long-range planning process, detailed investment planning, and portfolio prioritization exercises • Ensure cross-functional and cross-program sharing of key learnings, and drive change management as applicable Qualifications: • Direct experience in program management/program leadership for discovery through early clinical development programs; 6+ years in industry with 3+ years managing programs • Bachelor’s degree in relevant scientific area required, additional business training or education strongly desired; genetic medicines experience highly desired • Excellent verbal and written communication skills and strong interpersonal skills to manage relationships, set e

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