Executive Director, Supply Chain & External Manufacturing

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com . Prime Medicine is a clinical-stage biotechnology company creating the next generation of gene editing therapies. Our Prime Editing platform is versatile, precise, and efficient, with the potential to address more than 90% of known disease-causing genetic mutations. We have three programs in the clinic: an ex vivo cell therapy for an ultra-rare disease advancing toward a Biologics License Application (BLA), and two in vivo liver-targeting LNP Prime Editor programs, with more in development. We are a mission-driven team working in a lean, fast-moving environment. Position Overview Reporting directly to the Chief Technology Officer, the Executive Director of Supply Chain and External Manufacturing is a member of the Technology, Development and Operations (TDO) leadership team. You will own Prime Medicine’s end-to-end supply chain, from raw materials through clinical supply and commercialization, with direct accountability for materials management and for supporting internal planning and manufacturing needs. You will manage our external manufacturing partners, lead a highly functional lean team, and serve as the primary partner to Finance for TDO external spend. We are looking for a leader who embraces AI as a core part of how supply chain and external manufacturing run at Prime Medicine, from forecasting and materials visibility to partner performance and cost modeling. This role is for someone who thrives in ambiguity, is energized by building, and pairs strategic thinking with hands-on execution. Primary Responsibilities • Partner with the CTO and TDO leadership to define manufacturing and supply chain strategy, including network design, make-vs-buy decisions, and partner selection. • AI-enabled operations. Lead the use of AI and digital tools across supply chain and external manufacturing, including demand forecasting, materials and inventory visibility, partner performance monitoring, contract and cost modeling, and logistics tracking, as well as keeping the function ahead of new tools as they emerge. • Materials management. Own materials management across the portfolio, including forecasting, sourcing, purchasing, and inventory of raw materials, critical starting materials, and components, so materials are available on time for each program. • Planning and supply operations. Support internal planning and the manufacturing needs of each program; deliver labeling, packaging, shipping, and cell therapy logistics on time and in full; and resolve supply risks before they affect timelines. • External manufacturing and partners. Build and manage a netwo