Scientist, Genomics and Cancer Biology

Position Summary We are seeking a Scientist to drive multimodal genomics experiments supporting external BioPharma collaborations and internal discovery efforts. The Scientist will design, execute, and interpret studies that combine bulk and single-cell epigenomic and transcriptomic, spatial transcriptomic, and proteomic (including spatial proteomic) readouts on preclinical models and human patient samples, translating complex datasets into biological insight for pharma partners and internal programs. This is a hands-on, independent-contributor role for a scientist early in their industry career who combines strong cancer-biology judgment with technical depth across multiple genomic platforms and is comfortable working with computational scientists and project teams. Key Responsibilities • Drive end-to-end execution of multimodal genomics studies (e.g., DNA methylation/hydroxymethylation, chromatin accessibility and occupancy, RNA-seq, proteomics/phosphoproteomics) from experimental design through data delivery. • Plan and execute single-cell RNA-seq, spatial transcriptomics, and spatial proteomics experiments, including sample preparation, platform workflows, QC, and coordination with computational scientists for downstream analysis of cell types, states, and tissue architecture. • Translate collaborator and program questions (e.g., mechanism of action, therapeutic response, biomarker discovery) into fit-for-purpose experimental designs, sample plans, and assay panels. • Support external BioPharma collaborations: contribute to study scoping, execute studies to agreed timelines, communicate progress and results to partners, and contribute to reports and presentations. • Lead internal discovery experiments that generate and test hypotheses about cancer cell state, treatment response, and candidate biomarkers, including potential application to liquid-biopsy (cfDNA/ctDNA) profiling. • Generate high-quality NGS and, where applicable, mass-spectrometry datasets; perform library preparation, QC, and sequencing run management, and flag technical or batch effects. • Integrate multi-modal datasets using R and/or Python, in partnership with computational scientists, to identify signatures and prioritize candidates. • Implement and standardize laboratory workflows, including liquid-handling automation, to improve throughput and reproducibility across projects. • Maintain rigorous documentation, sample tracking, and data provenance; contribute to SOPs, technical reports, manuscripts, and patents. • Mentor and train junior staff and collaborators in experimental design and technical methods as needed. Minimum Qualifications • Ph.D. in Cancer Biology, Molecular Biology, Genetics/Genomics, Biochemistry, or a related field. • Plus ONE of the following: (a) at least 1 year of relevant industry experience (biotech, pharma, diagnostics, or equivalent), or (b) a completed postdoctoral fellowship. • Demonstrated experience with at least two genomic modalities (e.g., epigenomic sequencing, RNA-seq, proteomics) and with NGS library preparation and QC as evidenced in high quality publications. • Working proficiency in R and/or Python for genomic data analysis and visualization. • Demonstrated ability to work across wet-lab and computational teams, and to communicate results clearly in writing and verbally. • Strong desire to drive the utilization of novel technological approaches to answer difficult biological questions. Preferred Qualifications • Hands-on experience with single-cell RNA-seq, spatial transcriptomics and/or spatial proteomics platforms (e.g., sequencing-based or imaging-based spatial assays, multiplexed tissue imaging), including FFPE or fresh-frozen tissue handling. • Familiarity with ot