Director, Medical Affairs

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Job Summary: This role will be leading the medical affairs function at Keros Therapeutics. The ideal candidate is a career-motivated leader with a growth mindset who is eager to step up, take ownership of a lean function, and grow alongside the company. They are an exceptional communicator and collaborator who can independently execute a multi-asset strategy spanning neuromuscular, neurodegenerative, bone and fibrotic disorders. They will manage external engagement, scientific communications, and critically, serve as the primary internal champion for patient advocacy groups. Through close collaboration with key stakeholders, they will ensure medical insights are seamlessly integrated to support corporate decision-making and clinical development. Primary Responsibilities: • Lead the medical affairs function, establishing short-term stabilization and creating a long-term roadmap to scale the team as clinical assets progress. • Serve as the primary liaison and strategic lead for patient advocacy groups across DMD, ALS, and bone disorders, fostering trusted, long-term external relationships. • Drive the development and execution of the scientific communications strategy, including managing the medical publication planning, abstracts, and congress presentations. • Execute hands-on external engagement strategies, identifying, developing, and maintaining relationships with key opinion leaders (KOLs) and regional medical experts. • Act as the core medical affairs subject matter expert, partnering closely with Clinical Development, Clinical Operations, and Regulatory Affairs to support trial execution and insight generation. • Synthesize and communicate field-based medical insights to internal cross-functional teams to inform clinical strategy and program prioritization. • Manage external vendors, medical writing partners, and consultants supporting scientific communications and medical material generation to ensure high-quality deliverables. • Oversee the review and medical accuracy of scientific, regulatory, and corporate communication materials, ensuring compliance with relevant industry guidelines and SOPs. Qualifications: • Strong foundational experience or exposure to patient advocacy management, with a genuine passion for supporting rare disease communities (neuromuscular or bone disease experience is a major plus). • Proven ability to work effectively with minimal structure, with the agility to map out necessary processes and independently prioritize deliverables in a lean environment. • Demonstrated experience working with early-stage clinical assets and a strong understanding of the clinical development lifecycle. • Exceptional communication and interpersonal skills, with a track record of building trusted, strategic relationships with KOLs and external stakeholders. • Highly resilient, adaptable, and flexible mindset, with the proven ability to manage multiple distinct therapeutic areas simultaneously without losing focus. Education and Experience: • Advanced scientific degree (MD, PhD, PharmD, or equivalent) is preferred. • 5–8+ years of rele