TM China Associate Principal Scientist 2

Job Description / Capsule As a senior member of the China Translational Medicine (TM) team, funded by global Hematology TM, the role holder leads the development and delivery of China-specific TM strategies for complex clinical studies and across assigned programs. Working with the Head of China TM and global TM Leads (TMLs), the role holder integrates scientific objectives, China-specific clinical questions, local testing capabilities and applicable China requirements into globally aligned biomarker plans. The role provides scientific leadership for patient selection testing, exploratory analyses of clinical trial samples and translational science data generation through external laboratory partners. The role holder serves as the senior China TM cross-functional interface for assigned studies and programs, drives stakeholder alignment, and coordinates high-complexity governance support through integrated scientific input, clear recommendations and proactive management of risks and dependencies. Working with TM technology evaluation teams and relevant regulatory and Human Genetic Resources (HGR) specialists, the role holder leads scientific oversight of local technology providers, fit-for-purpose assay validation and testing quality. The role also develops local TM capability through training, mentoring and scientific guidance for junior China TML(s). The role holder is accountable for ensuring that all activities are delivered demonstrating behaviours and values aligned to AstraZeneca Code of Conduct and supporting policies, standards and procedures, including compliant management of Budget, Safety, Health and Environment.       Typical Accountabilities Provide China TM strategic and scientific leadership for complex clinical studies and assigned programmes, working in partnership with the Head of China TM, global TMLs and cross-functional teams. Lead the integration of China-specific scientific priorities, testing strategies and delivery requirements into globally aligned TM plans, with independent judgement and proactive management of complex risks, dependencies and stakeholder needs. .  • Lead China-specific TM strategy: Lead the development and delivery of China-specific biomarker and translational science strategies for complex clinical studies and assigned programs. Shape global TM plans through China-specific scientific, clinical and feasibility input, including protocol contributions and recommendations for local testing approaches. • Inform study design and development decisions: Provide scientific leadership to clinical project teams, translating China-specific clinical questions into biomarker objectives, patient selection and stratification approaches, exploratory analyses and data-generation plans that inform indication selection, assessment of biological activity and development decisions. • Coordinate high-complexity governance support: Lead the coordination of China TM inputs for complex study and program governance reviews. Integrate scientific and cross-functional contributions into decision-ready recommendations, options, trade-offs, risks and mitigation plans, and coordinate follow-through on resulting actions. • Drive stakeholder alignment and cross-functional coordination: Serve as the senior China TM interface for assigned studies and programs, connecting global TMLs, China clinical teams, regulatory and HGR specialists, TM technology groups and external testing partners. Align priorities, responsibilities and dependencies, resolve competing requirements, and escalate unresolved issues with clear recommendations. • Lead complex assay and laboratory strategies: Lead scientific oversight of local technology-provider evaluation, laboratory selection, assay deployment, fit-for-purpose validation and qua