Jobs / United States / Pfizer INC
Senior Principal Scientist
Pfizer INC · 🇺🇸 United States - New York - Pearl River
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 40 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 9 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Pfizer INC paid sponsored hires in similar roles2 certified filings for “SCIENTIST” (Biochemists and Biophysicists) in NY: $101k–$126k, median $113k. Most were filed at wage level II (50%) — 2 lottery entries, ≈31% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
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Sponsor Radar — Pfizer INC
The US Department of Labor certified 40 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 9 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Pfizer INC →
About the role
ROLE SUMMARY: This is a laboratory-based scientific leadership position within the Vaccines Research and Development Early Bioprocess Analytical and Formulation Development group. The Senior Principal Scientist will define and advance analytical strategies for early-phase vaccine candidates and adjuvant products, including proteins, mRNAs, conjugates, or combination modalities. The individual will manage and lead a group of scientists, providing direction, prioritization, coaching, and performance support to ensure strong scientific execution and professional development. The individual will serve as a recognized scientific resource, guide the development, qualification, transfer, and lifecycle management of separation-based, spectroscopic, mass spectrometry, and other physicochemical analytical methods, and provide high-impact technical recommendations across programs. Working with considerable autonomy, the individual will lead complex cross-functional initiatives, influence sub-function priorities, mentor scientists, and build innovative analytical capabilities that enable timely, data-driven vaccine development. ROLE RESPONSIBILITIES: • Define and lead analytical control strategies for multiple vaccine programs, aligning method capabilities, product quality attributes, program risks, and development milestones. • Manage and lead a group of scientists, providing direction, prioritization, coaching, and performance support to ensure strong scientific execution and professional development. • Provide scientific leadership for the development, optimization, qualification, transfer, and lifecycle management of separation-based, spectroscopic, mass spectrometry, and other physicochemical analytical methods. • Independently resolve complex and ambiguous analytical challenges by integrating mechanistic understanding, experimental design, literature, platform knowledge, and cross-disciplinary input. • Represent Analytical Development on cross-functional project teams; communicate risks, options, and data-driven recommendations to scientific and program leadership. • Lead innovation in analytical technologies, AI, automation, digital tools, and data analytics to improve scientific insight, throughput, robustness, and decision quality. • Direct the authoring and technical review of analytical methods, protocols, development and qualification reports, specifications, certificates of analysis, stability documents, and relevant regulatory content. • Develop analytical talent through formal and informal mentoring, technical coaching, experimental review, and opportunities for colleagues to lead and present scientific work. • Forecast priorities and resource needs across programs, coordinate matrixed contributions, and ensure delivery of high-quality data and documentation in accordance with data integrity, safety, and applicable quality expectations. BASIC QUALIFICATIONS: • PHD with at least 8+ years of relevant experience in analytical chemistry, biochemistry, pharmaceutical sciences, or a related discipline. • Advanced expertise in analytical method development and characterization of biologics, vaccines, or complex modalities, with demonstrated ability to set analytical strategy and solve complex technical problems. • Demonstrated experience managing and leading scientific teams, including setting priorities, providing technical and professional guidance, coaching talent, and enabling strong scientific execution. • Extensive hands-on and scientific leadership experience with separation-based techniques such as liquid chromatography or capillary electrophoresis. • Demonstrated record of leading method development, qualification, transfer, troubleshooting, and technical documentation across multiple programs or development s