Jobs / United States / Astrazeneca Pharmaceuticals Lp
Associate Director, CMC Lead
Astrazeneca Pharmaceuticals Lp · 🇺🇸 US - Boston - MA
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Astrazeneca Pharmaceuticals Lp paid sponsored hires in similar roles4 certified filings for “Associate Director, Precision Medicine” (Medical Scientists, Except Epidemiologists) in MA: $179k–$260k, median $215k. Most were filed at wage level II (75%) — 2 lottery entries, ≈31% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
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Sponsor Radar — Astrazeneca Pharmaceuticals Lp
The US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Astrazeneca Pharmaceuticals Lp →
About the role
Job Title: Associate Director, CMC Lead Introduction to role: Are you ready to lead early-stage CMC strategy that turns precision radioconjugate science into first-in-human reality? As Associate Director, CMC Lead, you will steer development across a portfolio of alpha-emitting, tumor-targeted medicines, shaping IND-enabling plans and building the foundations for reliable, phase-appropriate clinical supply. Your decisions will determine how fast promising candidates move from discovery to patients. You will join a team pushing the boundaries of oncology through novel radioconjugates and smart combinations, supported by state-of-the-art radiopharmaceutical manufacturing capabilities and an advancing clinical pipeline. How will you prioritize across multiple candidates, balance scientific rigor with speed, and de-risk the path to first-in-human studies? If you thrive in a dynamic, matrixed environment and enjoy solving complex CMC puzzles, this role puts you at the center of impact. Accountabilities: • Phase 0 CMC Strategy: Define and deliver the pharmaceutical development strategy for the pre-IND/IND-enabling portfolio to drive timely progression to first-in-human readiness. • IND/IMPD Readiness: Lead CMC regulatory strategy; guide and contribute to authoring high-quality documentation and data packages for IND/IMPD submissions. • API/Drug Product/Analytical Integration: Coordinate API, drug product, and analytical development to establish robust, scalable, phase-appropriate processes and methods. • Clinical Supply Strategy: Build and execute supply strategies for Phase 0/Phase I, aligning isotope availability, shelf life, and study timelines to ensure on-time, fit-for-purpose clinical material. • Portfolio Leadership: Manage multiple early-stage programs; set priorities, balance resources, and adjust strategies as data emerge to protect the critical path. • Cross-Functional Influence: Represent CMC on project teams; shape overall program strategies and inform candidate selection through clear, data-driven risk/benefit assessments. • Target and Modality Assessment: Evaluate new molecular targets and modalities for CMC feasibility and developability to guide investment decisions. • Transition Enablement: Partner with Program Management, Clinical, Research, Regulatory, Quality, and Supply Chain to enable seamless movement of candidates from research into early development. Essential Skills/Experience: • 7+ years of experience in pharmaceutical/biopharmaceutical product development and manufacturing; • Minimum education: Bachelor's degree. Advanced degree in Biochemistry, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, Chemical Engineering, or related scientific discipline preferred. • Demonstrated experience managing early-phase CMC development, including IND-enabling activities, process development, and analytical method development. • Strong project leadership skills with the ability to manage multiple concurrent programs at varying stages of maturity. • Demonstrated strong interpersonal and communication skills with the ability to collaborate effectively across functions and influence stakeholders at multiple levels of the organization. • Ability to develop and implement phase-appropriate pharmaceutical strategies across CMC areas (API, DP, Analytical) aligned with overall program objectives and timelines. • Experience working in a matrix environment and leading cross-functional sub-teams to deliver against defined milestones. • Strong problem-solving aptitude with the ability to navigate ambiguity and make sound technical and strategic judgments in a data-limited, early-stage environment. Desirable Skills/Experience: • Experience with radiopharmaceuticals or radioconjugates, including awarene