Jobs / United States / Astrazeneca Pharmaceuticals Lp
Principal Process Engineer
Astrazeneca Pharmaceuticals Lp · 🇺🇸 US - Mt. Vernon - IN
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Astrazeneca Pharmaceuticals Lp paid sponsored hires in similar roles2 certified filings for “Senior Platform Engineer - CRM Applications” (Information Technology Project Managers) in DE: $149k–$176k, median $163k. Most were filed at wage level III (50%) — 3 lottery entries, ≈46% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
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Sponsor Radar — Astrazeneca Pharmaceuticals Lp
The US Department of Labor certified 99 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 31 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Astrazeneca Pharmaceuticals Lp →
About the role
Key Accountabilities The role of the Principal Process Engineer has the following responsibilities: • Serve as skill area leader for pharmaceutical unit operations with a focus on the mechanistic understanding of process-equipment interface. • Lead of technical strategic initiatives, networks or forums within the organization related to pharmaceutical manufacturing processes and equipment. • Executing Technical Leadership and influencing across Operations. • Apply process engineering principles to identify opportunities for, develop and deploy reduced-order mechanistic and physics-informed process models based on first-principles engineering and equipment geometry (e.g. mass, energy and momentum balances) to predict process performance, resolve operational issues, support scale-up and optimise equipment and system integration. • Provide technical leadership and expertise in resolving complex manufacturing challenges through the application of first-principles engineering analysis, mechanistic modelling and simulation, developing fit-for-purpose reduced-order models to identify root causes, assess risks and improve process performance. • Contribute to product supply strategy projects, including sourcing, asset transfers, capacity expansions, and the introduction of new equipment. • Lead technical support for the transfer of established product manufacturing processes within internal manufacturing sites and to external partners, employing scale-up modelling, equipment selection, and comprehensive manufacturing engineering support. • Identify opportunities for manufacturing improvement, lead impact assessments, and support the implementation of technical improvements or major change initiatives with a focus on maintaining product performance, including contributions to regulatory file authoring, license renewals, and responses to regulatory queries, supported by model-based risk assessments. • Drive the standardisation and modernisation of manufacturing equipment and processes across Operations, leveraging advanced modelling and simulation to meet regulatory requirements, support good business practices, and ensure manufacturability and quality standards. Required Skills & Knowledge • Demonstrate an understanding of the overall drug development and commercialization process from development, launch, and through life cycle management. • Process/chemical Engineering BSc/MSc with 7+ years of relevant pharmaceutical industry experience post degree or PhD level with 5+ years of experience post degree • Demonstrate an understanding of pharmaceutical product End-to-End Control Strategy (CS) and/or Enhanced Control Strategy (ECS). • Have demonstrated experience in the development and application of reduced-order mechanistic and physics-informed models of pharmaceutical unit operations and equipment (e.g. mixing, drying, compression, roller compaction, continuous direct compression and coating), including models derived from equipment geometry and first-principles engineering relationships such as mass and energy balances. • Demonstrate an understanding of physical characterisation of raw material, intermediate and final products and impact on manufacturing process robustness (e.g. mechanical testing, PSD, imaging etc). • Have experience in scientific programming, data analysis and digital tools used to develop, implement and maintain mechanistic and hybrid (physics-informed) process models. • Have experience with a range of CMC elements related to commercial product manufacturing process requirements – e.g., process establishment, optimisation and validation, control of drug products, stability, packaging and commercial manufacturing, with good understanding of SHE and cGMP. • Experience in Pharmaceutical Operations and/