Jobs / United States / Regeneron Pharmaceuticals INC
Senior Principal Scientist - Microscopy
Regeneron Pharmaceuticals INC · 🇺🇸 TARRYTOWN
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 290 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 40 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Regeneron Pharmaceuticals INC paid sponsored hires in similar roles60 certified filings for “Principal Scientist” (Biochemists and Biophysicists) in NY: $100k–$153k, median $136k. Most were filed at wage level II (85%) — 2 lottery entries, ≈31% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
A verdict summarises public evidence; it is not legal advice and never a guarantee — the employer and the immigration authority decide. Sign in to factor in where you can already work.
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Sponsor Radar — Regeneron Pharmaceuticals INC
The US Department of Labor certified 290 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest Jun 2026) — the step every H-1B hire needs first. USCIS also records 40 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Regeneron Pharmaceuticals INC →
About the role
Senior Principal Scientist of Microscopy Build our future together: Regeneron is seeking an accomplished and innovative scientist to lead the Microscopy function within Imaging Sciences. The successful candidate will be a recognized expert in microscopy with deep expertise in cell biology, advanced optical imaging technologies, quantitative image analysis, and scientific leadership. This individual will provide scientific and strategic leadership for a multidisciplinary microscopy team supporting discovery research, technology development, translational science, and early therapeutic programs across Regeneron's research portfolio. The role will build upon the core's current capabilities while driving the future vision of imaging sciences through the adoption of emerging microscopy technologies, automation, AI-enabled analytics, multidimensional imaging workflows, and integrated imaging solutions. The ideal candidate combines outstanding scientific credentials as a practicing microscopist with a demonstrated track record of managing and growing a microscopy core facility, mentoring staff scientists, and partnering effectively with researchers across diverse therapeutic areas. When & where: Location: Tarrytown, NY United States – On-site Discover your role: • Advance the scientific direction for microscopy and cellular imaging across Regeneron Research, aligning capabilities with priority biological and therapeutic questions. • Identify, evaluate, validate, and adopt emerging technologies based on scientific value, technical performance, scalability, and portfolio need. • Provide senior consultation that translates complex biological questions into fit-for-purpose imaging strategies, experimental designs, and quantitative readouts. • Lead, develop, and retain a high-performing multidisciplinary microscopy team and foster a culture of scientific rigor, collaboration, innovation, and continuous learning. • Oversee annual strategic, operational, workforce, and capital-equipment plans for the microscopy function. • Establish governance, metrics, workflows, training, and service models that improve quality, accessibility, reliability, turnaround time, and scientific impact. • Provide scientific leadership across advanced optical, super-resolution, spectral, lifetime, label-free, live-cell, 3D, high-content, high-throughput, spatial, and translational microscopy approaches. • Guide method selection, assay development, experimental design, technology troubleshooting, and quantitative image analysis, including machine-learning-enabled approaches. • Develop scalable imaging infrastructure spanning laboratory automation, robotic image acquisition, image-data management, cloud analytics, AI applications, and digital microscopy. • Integrate microscopy with molecular imaging, histology, pathology, spatial biology, and other Imaging Sciences platforms to generate coherent, cross-scale evidence. • Partner with discovery, translational, platform, engineering, data science, and technology teams to deliver imaging strategies that inform target validation, mechanism-of-action studies, biomarker development, candidate selection, and translational planning. • Mentor microscopy scientists and imaging specialists, build technical depth and scientific leadership, and train researchers in microscopy best practices and experimental design. This role requires: • A Ph.D. in Cell Biology, Cellular Physiology, Developmental Biology, Molecular Biology, Bioengineering, Biophysics, or related discipline. • Minimum 5 years of relevant postdoctoral and/or industry experience. • Minimum 5 years leading a microscopy core facility or equivalent scientific organization. • Demonstrated expertise developing and applying advanced microscopy methodologi