Senior Scientist Translational Developability

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About the role

We are currently seeking an enthusiastic, dynamic and self-motivated senior scientist to join the Translational Developability group within MDE and working within a matrix role.  The role will be primarily lab focused, working with teams of scientists with diverse skills including protein biochemists, in vitro and ex vivo assay scientists, antibody pharmacologists and molecular biologists as well as in close partnership with other parts of the GSK organisation.  It involves using high throughput methods to rapidly profile large panels of antibodies and perform interpretations on the generated data in the early discovery phase. These activities will focus on in vitro prediction of antibody characteristics during exposure in vivo . Large Molecule Research within GSK is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling. Within the Large Molecule Discovery Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling prior to candidate selection to continuously improve molecule quality and transform discovered leads into potential therapeutics. As a Senior Scientist, you will lead laboratory science to characterise and de-risk therapeutic antibody and biopharmaceutical candidates. You will work closely with colleagues in discovery and early development to design and run experiments that deliver clear decision-making data.   This role offers hands-on laboratory work, scientific ownership, and opportunities to develop both technical and leadership capabilities while contributing to the progression of innovative therapies.   We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work. Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK   In this role you will • Design and deliver experiments to characterise antibody-based molecules using a range of techniques such as chromatography-based analytical techniques such as SEC-HPLC and CIEX-HPLC, as well as ELISA and flow-based assays. • Analyse and interpret experimental data to provide clear, actionable recommendations to project teams. • Collaborate within multidisciplinary teams to support programme progression and scientific decision making. • Maintain accurate experimental records and produce high-quality documentation including formal reports. • Contribute to assay development, qualification, and optimisation to improve throughput and data quality. • Promote safe laboratory practices and support equipment and reagent management. Why you? Basic Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: • Advanced degree (PhD or MSc with relevant laboratory expertise) in biochemistry, biophysics, pharmacology or related life science discipline, or BSc with equivalent experience. • Independence and competence performing relevant analytical/ biological research techniques (in one or more of the following: immunoassay, flow cytometry, SEC- HPLC ); • Pharmaceutical, Biotech, or CRO industry experience working on large molecules and knowledge

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