Manufacturing Shift Team Lead

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About the role

Title: Manufacturing Shift Team Lead GCL D Introduction to role: Be part of history in the making. AstraZeneca is building its first biologics manufacturing campus in Singapore — a groundbreaking USD 1.5 billion investment that will serve as a global hub for innovation and excellence. This state-of-the-art facility will deliver end-to-end Antibody-Drug Conjugate (ADC) capabilities with different manufacturing units/buildings in one campus   • Small molecule- chemical API production • Large molecule- monoclonal antibody manufacturing • Conjugation • Fill-and-finish operations, including sterile filling and lyophilization • Final secondary packaging The campus will be equipped with modern digital and automation infrastructure, enabling autonomous manufacturing powered by artificial intelligence. In addition, it will be designed for carbon neutrality, embedding sustainability into every aspect of operations and setting a new benchmark for environmentally responsible biologics manufacturing. We are looking for passionate individuals with relevant experience who thrive in dynamic environments and bring a “make-it-happen” attitude. Joining us means contributing to a project that will not only transform AstraZeneca’s global supply chain but also advance life-changing medicines for patients everywhere. If you’re ready to shape the future of biologics and be part of a once-in-a-generation project, we want you on our team. Introduction to role: Are you ready to lead a high-performing manufacturing shift that turns pioneering science into reliable supply for patients? Can you anticipate risks on the shopfloor, rally a team around the plan, and deliver right-first-time batches in a fast-moving, highly regulated environment? Based at our Singapore site, you will lead day-to-day execution of the shift production plan for an innovative facility. You will set the pace for safe, compliant and efficient operations, ensuring people, equipment, materials and documentation are ready before work begins. By partnering closely with Quality, Engineering, Safety, Warehouse, Laboratory and technical teams, you will keep production on track, resolve issues effectively, and sustain inspection readiness. This role is built for leaders who thrive at the point of execution—where decisions matter in the moment and outcomes directly impact patients. If you want to grow your capability while guiding a skilled team through complex manufacturing activities, this is your opportunity to make a tangible difference. Accountabilities: • Safety, Quality and Compliance Leadership: Lead the shift in line with batch records, SOPs, permits and cGMP requirements; promote a speak-up, safety-first culture; and take decisive action to stop or place operations in a safe state when risk arises, preserving evidence and escalating appropriately. • Shift Plan Delivery and Operational Control: Translate the production schedule into an executable shift plan, assign work by technician capability, verify readiness of personnel, equipment and materials, and maintain oversight of critical steps, alarms, excursions and abnormal conditions to protect product and schedule. • Team Leadership and Capability: Set clear expectations, run effective start-up and handover tier meetings, provide visible shopfloor leadership, mentor technicians, reinforce procedural subject area and maintain training awareness to ensure robust shift coverage and resilience. • Deviation, Investigation and Change Management: Ensure abnormalities are contained and documented with initial impact assessments; lead or support structured troubleshooting, root-cause analysis and timely CAPA closure; and support change controls, risk assessments, validation and inspection readiness. • Cross-functional Coordinatio

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