Jobs / Singapore / Astrazeneca Pharmaceuticals Lp
Associate Director, Manufacturing
Astrazeneca Pharmaceuticals Lp · 🌍 Singapore
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Sponsor Radar — Astrazeneca Pharmaceuticals Lp
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About the role
Job Title: Associate Director of Manufacturing GCL E Introduction to role: Be part of history in the making. AstraZeneca is building its first biologics manufacturing campus in Singapore — a groundbreaking USD 1.5 billion investment that will serve as a global hub for innovation and excellence. This innovative facility will deliver end-to-end Antibody-Drug Conjugate (ADC) capabilities with different manufacturing units/buildings in one campus • Small molecule- chemical API production • Large molecule- monoclonal antibody manufacturing • Conjugation • Fill-and-finish operations, including sterile filling and lyophilization • Final secondary packaging The campus will be equipped with modern digital and automation infrastructure, enabling autonomous manufacturing powered by artificial intelligence. In addition, it will be designed for carbon neutrality, embedding sustainability into every aspect of operations and setting a new benchmark for environmentally responsible biologics' manufacturing. We are looking for passionate individuals with relevant experience who thrive in dynamic environments and bring a “make-it-happen” attitude. Joining us means contributing to a project that will not only transform AstraZeneca’s global supply chain but also advance life-changing medicines for patients everywhere. If you’re ready to shape the future of biologics and be part of a once-in-a-generation project, we want you on our team. 1. Introduction to role: Are you ready to lead end-to-end GMP manufacturing execution that turns pioneering therapies into reliable reality for patients? This role anchors day-to-day operations for our Singapore ADC manufacturing buildings, translating strategy into safe, compliant and dependable performance across shifts. Your leadership will keep complex operations flowing, ensure right-first-time outcomes and build team capability to meet an ambitious, fast-evolving production schedule. You will create the conditions for consistent shopfloor excellence, integrating manufacturing support, digital workflows and continuous improvement so that batches move on time and issues are resolved with subject area and pace. How will you shape a high-performing, inspection-ready operation that scales with our pipeline and drives measurable gains in safety, quality, delivery, cost and people development? 2. Accountabilities: Manufacturing Execution and Schedule Control: Lead daily and weekly execution of the approved production plan across shifts, setting clear priorities, deploying resources effectively and running disciplined critical issue to protect safe batch progression and schedule adherence. Shopfloor Leadership and Right-First-Time Performance: Maintain visible leadership on the floor, coach first line leaders at the point of execution, reinforce standard work and data-driven behaviors, and close performance gaps promptly to deliver right-first-time outcomes. Safety, Containment, Quality and Compliance: Uphold cGMP, process safety, occupational safety, containment controls and local requirements; ensure hazards and operational risks are understood and controlled before and during execution. Deviation, Investigation and CAPA Delivery: Ensure timely initiation and operational ownership of deviations; lead or sponsor structured root cause analysis and deliver effective CAPAs that reduce recurrence and improve control. Operational Readiness and Handover: Drive manufacturing readiness for assigned systems, areas and campaigns, including procedures, batch records, training, staffing, line readiness, materials, cleaning, digital workflows and acceptance of qualified equipment into routine oper ations. Cross-Functional Constraint Removal: Coordinate day-to-day delivery with QA, QC, Engineering, Validation,