Jobs / United States / Twist Bioscience Corporation
Manager, Site Reliability Engineer
Twist Bioscience Corporation · 🇺🇸 USA - South San Francisco, CA
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 11 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest May 2026) — the step every H-1B hire needs first. USCIS also records 9 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Twist Bioscience Corporation paid sponsored hires in similar roles1 certified filing for “Senior Automation Engineer, Test Automation” (Software Quality Assurance Analysts and Testers) in CA: $145k–$145k, median $145k. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
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Sponsor Radar — Twist Bioscience Corporation
The US Department of Labor certified 11 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest May 2026) — the step every H-1B hire needs first. USCIS also records 9 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Twist Bioscience Corporation →
About the role
Manager, Site Reliability Engineer (Hybrid in South San Francisco) About the Role We are seeking an experienced and hands-on Site Reliability Engineering (SRE) Manager to lead our Site Operations and infrastructure initiatives. This role is responsible for ensuring the reliability, scalability, security, and performance of our cloud infrastructure and critical applications. The ideal candidate combines strong technical expertise with leadership experience and a passion for operational excellence. You will lead efforts across cloud infrastructure, observability, automation, networking, and platform reliability while partnering closely with engineering and product teams to support business-critical applications. Responsibilities • Lead and manage the Site Operations / SRE function • Own cloud infrastructure architecture, operations, scalability, and optimization • Ensure high availability and reliability of production applications and services • Drive operational excellence through automation, monitoring, and incident management • Develop and maintain observability platforms including logging, metrics, alerting, and tracing • Manage Kubernetes-based infrastructure and container orchestration environments • Oversee networking, DNS, CDN, and storage infrastructure across cloud environments • Collaborate with software engineering teams to improve deployment processes, system resilience, and performance • Establish and improve CI/CD pipelines and infrastructure-as-code practices • Lead incident response, root cause analysis, and post-incident remediation efforts • Manage vendor and platform relationships where applicable • Mentor and develop SRE / Site Operations engineers and foster a culture of reliability and continuous improvement • Define and implement infrastructure security and compliance best practices Required Qualifications • 5–7+ years of experience in Site Operations, Site Reliability Engineering, Infrastructure Engineering, or related operational roles • Prior experience leading or mentoring engineering or operations teams • Strong hands-on experience with cloud infrastructure platforms (AWS, Azure, and/or GCP) • Experience managing Kubernetes (K8s) environments in production • Strong understanding of networking concepts including DNS, load balancing, firewalls, routing, and CDN technologies • Experience with Akamai CDN administration and optimization • Experience with observability and monitoring platforms, including Splunk • Experience with storage infrastructure and cloud-native storage solutions • Strong scripting and automation experience (Python, Bash, Terraform, or similar) • Experience implementing and maintaining CI/CD pipelines • Strong troubleshooting and incident management skills in complex distributed systems • Excellent communication and cross-functional collaboration skills Preferred Qualifications • Experience managing hybrid or multi-cloud environments • Experience with infrastructure-as-code and GitOps methodologies • Familiarity with security best practices and compliance frameworks • Experience supporting highly available enterprise or SaaS platforms • Strong understanding of container security and cloud-native architectures About Twist Bioscience Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA. At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers. Twist Bioscience