Jobs / United States / Twist Bioscience Corporation
Sr Staff Program Manager, MES Custom Software Development Transformation
Twist Bioscience Corporation · 🇺🇸 USA - South San Francisco, CA
Sponsorship verdict
Sponsorship possible
One solid signal, not two — worth applying, and worth asking about sponsorship early.
- Employer is on a government sponsor recordThe US Department of Labor certified 11 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest May 2026) — the step every H-1B hire needs first. USCIS also records 9 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
- The posting doesn’t mention sponsorshipSilence isn’t a refusal — ask the recruiter before investing much time.
- No salary bar for this routeH-1B has no fixed salary bar: the employer must pay at least the prevailing wage for the role and area. Cap-subject employers enter a lottery weighted by wage level. Source: https://www.federalregister.gov/documents/2025/12/29/2025-23853/weighted-selection-process-for-registrants-and-petitioners-seeking-to-file-cap-subject-h-1b, rules effective 2026-02-27.
- What Twist Bioscience Corporation paid sponsored hires in similar roles1 certified filing for “Software Development Engineer” (Software Developers) in CA: $136k–$136k, median $136k. Most were filed at wage level I (100%) — 1 lottery entry, ≈15% projected selection odds for cap-subject employers. Source: US Department of Labor LCA disclosure data (Oct 2025 – Jun 2026).
- Confirmed live todayWhen a source last listed this job as open.
US H-1B: cap-subject employers enter a lottery weighted by wage level — Level I gets 1 entry, Level IV gets 4 (DHS projected selection odds ≈15% at Level I to ≈61% at Level IV). Universities and non-profit research employers are cap-exempt. The $100,000 fee for new petitions from abroad is currently blocked by a court order (appeal pending).
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Sponsor Radar — Twist Bioscience Corporation
The US Department of Labor certified 11 H-1B/E-3 labor condition applications for this employer between Oct 2025 and Jun 2026 (latest May 2026) — the step every H-1B hire needs first. USCIS also records 9 H-1B approvals in FY2023. Source: LCA disclosure data (US Department of Labor (OFLC)).
Past sponsorship or register membership never guarantees sponsorship for this vacancy or for you. Full Sponsor Radar for Twist Bioscience Corporation →
About the role
Sr Staff Program Manager, MES Custom Software Development Transformation (Hybrid in South San Francisco, CA or Wilsonville, OR) Summary Twist Bioscience is embarking on a strategic transformation of its Manufacturing Execution System (MES) to modernize our technology platform, enable operational scalability, and support the evolving needs of our business. We are seeking an experienced Sr Staff Program Manager to drive the strategic planning, cross-functional coordination, and hands-on execution of this business-critical initiative. Reporting directly to the Sr Director of Technology Operations, this role will lead the delivery of the MES replatform efforts, bringing structure, Agile delivery discipline, and strong program governance to ensure successful execution. Partnering closely with Technology, Manufacturing Operations, R&D, Quality, and business stakeholders, this individual will be responsible for aligning priorities, managing complex dependencies, and driving decisions. Key Responsibilities • Strategic Program Leadership: Lead the overall MES replatform transformation, translating strategic objective into an actionable, integrated program roadmap. • MES Project Execution: Lead day-to-day execution of the MES replatform, managing timelines, scope, resources, and deliverable milestones. • Stakeholder Engagement: Partner closely with business users, IT process owners, and external software vendors/agencies to communicate status, align expectations, and resolve cross-functional issues. • Budget & Resource Management: Track project expenditures, support financial budgeting, and ensure efficient resource allocation across core initiative tracks. • Process & Change Optimization: Implement company and departmental procedures that affect immediate operations. Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms. • Risk & Quality Management: Proactively identify technical, operational, and integration risks. Enforce quality-control practices, compliance standards, and validation protocols required in manufacturing software environments. Qualifications • Education: Bachelor’s degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field. • Overall experience: Minimum of 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations. • Agile & Delivery Expertise: Proven expertise in Agile project delivery frameworks (Scrum Master, SAFe, or PMI-ACP certifications preferred) with a strong track record of facilitating Agile ceremonies and managing iteration cycles. • Project Leadership: 5 plus years in project or program management leading cross-functional custom software development teams. • Solid hands-on understanding of the custom software development lifecycle (SDLC), modern software architecture principles, and business transformation frameworks. Biotech or pharmaceutical industry experience is preferred. • Strong leadership, negotiation, and conflict-resolution skills, with a track record of translating complex manufacturing requirements into actionable software solutions. Preferred Qualifications • Certifications: Certified ScrumMaster (CSM), PMI-ACP, or SAFe Agilist. • Industry Focus: Specialized experience in biotech, pharmaceutical, semiconductor, or advanced discrete manufacturing environments. • Domain Knowledge: Deep understanding of custom software development lifecycles (SDLC), shop-floor manufacturing processes, SCADA/PLC integration, and ISA-95 standards. About Twist Bioscience Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the