Scientist, Synthetic Biology

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About the role

Company Overview: Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety. Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA. Become the next standout single strand! Job Summary: We are looking for a highly motivated and innovative candidate for the role of Scientist of Synthetic Biology. The ideal candidate will use fundamental biological design principles to build RNA-based genetic circuits to facilitate drug discovery and development. This is a fantastic opportunity to make a significant impact as a scientifically motivated self-starter capable of independently conceiving, conducting, and critically analyzing their own work with minimal supervision. Primary Responsibilities: • Design and develop synthetic genetic constructs to enable programmable, cell-type specific gene expression. • Build and test engineered circuits for desirable phenotypes in relevant cell systems in vitro thus validating predicted designs. • Plan experiments utilizing molecular techniques including molecular cloning, mammalian cell transfection, flow cytometry, ELISA, qPCR, Western blot etc. • Maintain proper records in electronic notebook and contribute to writing protocols • Communicate experimental methods and results to fellow team members and work closely with cross-functional teams. Qualifications: • PhD in Biomedical Engineering, Boinformatics, or requivalent required. • 1-2 years of professional research experience in industrial and/or academia required. • Ability to plan, design and execute experiments as part of a project, communicate findings to a diverse audience, and iterate on ideas for optimizing genetic circuit designs for a desired behavior. • Experience with cellular and molecular biology techniques like molecular cloning, qPCR, mammalian cell culture, and transfection required. • Prior experience with flow cytometry, image analysis, and automation equipment is a plus. • Hands-on experience with in vitro transcription of mRNA required. • Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment. • A strong team player with excellent oral and written communication skills and a demonstrated ability to work independently. • Independently motivated, detail oriented and good problem-solving ability. • Excellent organizational skills and attention to detail. Strand offers a fast-paced, entrepreneurial, team-focused small company environment. We also offer a top-n

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