Senior Manager, Program Management

MISSION Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously. POSITION SUMMARY The Senior Program Manager, Drug Development will partner with the Program Lead and cross-functional Development Team to shape and execute integrated program strategy and long-range plans from preclinical development through regulatory approval and commercialization. This role will drive team alignment and disciplined execution across scope, schedule, risks and issues, budget, resources, governance, and stakeholder communications. The Senior Program Manager will connect research, CMC, nonclinical, clinical, regulatory, and commercial functions to ensure clear goals, informed decisions, and coordinated delivery of key program milestones. JOB FUNCTIONS/RESPONSIBILITIES In this role, you will partner with Program Team Lead to lead integrated program planning and execution, enable effective cross-functional governance, and help teams anticipate and navigate key development decisions. • Support Program Lead and Development Team members to develop, maintain, and execute the cross-functional program strategy and integrated development plan. • Establish and maintain functionally integrated program schedules that enable accurate analysis of critical path activities, dependencies, milestones, and resource constraints. • Identify, assess, and track program risks and issues; facilitate mitigation and contingency planning and escalate material concerns through the appropriate governance channels. • Support Program Lead and Development Team members to develop scenario planning around key milestones and decision points, helping teams evaluate trade-offs, prepare alternative outcomes, and identify opportunities to accelerate development. • Connect short-, mid-, and long-term plans across functions and proactively highlight interdependencies, assumptions, and potential impacts to program objectives. • Partners with the program lead to facilitate cross-functional team and governance meetings, including agenda development, decision framing, documentation of outcomes, and follow-through actions. • Drive timely, transparent program reporting for stakeholders and leadership, including progress against milestones, key decisions, risks, resource needs, and team accomplishments. • Build strong relationships with functional partners and leaders across research, CMC, nonclinical, clinical development and operations, regulatory, and commercial teams. • Serve as a Program Management subject matter resource and contribute to the continued evolution of Program Management tools, processes, standards, and ways of working. • Contribute to Program Management department goals and initiatives; may provide coaching, mentorship, or oversight to other Program Management staff. • Perform other duties as assigned. QUALIFICATIONS Education/Experience: • BA/BS in a life sciences discipline with 5+ years of multidisciplinary pharmaceutical or biotechnology industry experience in program management; or a master’s or PhD degree with 4+ years of relevant experience. • Experience supporting l drug development programs through key clinical and/or regulatory milestones demonstrating knowledge of the drug development process. • Demonstrated understanding of program and project management practices, tools, and methodologies, including integrated planning, critical path analysis, risk management, scenario planning, and sta