Senior Manager, Financial Planning & Analysis

About Stoke: Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/ Position Purpose: The Senior Manager , FP& A will play a n integral role in supporting the Company’s financial planning, analysis and close processes, contributing to continued growth . The focus of this position will be playing a key role in the forecasting, budgeting and long-range planning processes, as well as supporting the month-end / quarter-end close process es . This person may also serve as a business partner to select departments. This person will work closely with t he FP&A team, Accounting and department heads as needed to understand and support the performance of their respective areas . This individual will maintain and continuously update, with attention to detail, the Company’s existing internal financial model , ensuring it reflects updated budgets, changing business needs and other strategic considerations. They will provide analytical support to the FP&A team, including preparing Executive Leadership Team (ELT) presentations and assisting with ad hoc analyse s and other projects as requested . We are looking for a highly motivated team member who will start in a supporting capacity and have the opportunity to grow into owning parts of these processes over time . The position reports to the Director, FP&A . Key Responsibilities: • Support the annual budgeting, quarterly forecasting and long-range planning processes. • Perform month-end and quarter-end variance analysis. Identify, interpret and explain budget and expense variances: analyze cost variances, actual vs. plan/forecast and actual vs. prior period, review with departments. • Provide regularly recurring reports that summarize operational results and forecasts, including department performance against financial, strategic and operational targets, with timely communication of opportunities and risks to relevant stakeholders; routinely communicate business, financial, and operational performance trends, historical and forecasted, using appropriate metrics. • Support the Company’s collaborations, including invoicing, collaboration reporting, and ad hoc data requests. • Partner with select departments as needed to ensure accurate monthly financial reporting and provide ongoing financial and analytical support. • Support Clinical Operations by reviewing CRO agreements and clinical program reporting, as well as assisting with clinical trial budgeting activities ; prior exposure to clinical operations finance is strongly preferred . • Maintain and update the existing financial model and forecasting models for both planning and accrual recognition, ensuring accuracy and strong attention to detail. • Prepare Executive Leadership Team (ELT) slides each month and quarter and provide financial support for Board presentation preparation. • Implement b est p ractices/ p olicies as defined by int