Senior / Principal Scientist, Medicinal Chemistry

Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at altoslabs.com. Our Value Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission . Diversity at Altos Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos We are seeking a talented and passionate Medicinal Chemist to join our small-molecule drug discovery team. In this role, you will advance science and develop life-changing medicines. You will impact all stages of drug discovery, from hit identification to lead optimization, within a collaborative and fast-paced environment. Responsibilities Include: • Drive Drug Discovery Programs: Contribute to the chemistry efforts for one or more drug discovery programs, focusing on designing drug-like molecules and optimizing compounds towards drug development candidate selection. • Collaborate Cross-Functionally: Work closely with a diverse range of functions, including Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology. • Design and Synthesize Novel Compounds: Apply innovative structure-based, computational, and property-based design tools and methods, and/or synthesize analogs for molecular targets. This includes conducting multi-step syntheses, retrosynthetic analysis of complex molecules, and troubleshooting synthetic issues internally or with CRO partners. • Analyze and Interpret Data: Utilize strong analytical thinking skills to organize, analyze and communicate structure-activity relationship (SAR) data sets to drive design ideas and impact program direction. • Solve Complex Problems: Design compounds that effectively address challenges related to potency, physical properties, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity). • Support Chemistry Operations: Execute synthesis within internal laboratories, collaborate with Contract Research Organizations (CROs), and provide broad general chemistry support to all functions within Altos Labs. • Communicate and Present: Deliver effective presentations and articulate scientific findings clearly to both internal and external stakeholders. • Potential for Leadership: Demonstrate leadership potential towards leading chemistry programs, including managing external CRO chemistry FTEs. Who You Are • Education and Experience: You possess a Ph.D. in Organic Chemistry with 6+ years of post-Ph.D. experience, or equivalent and relevant experience in chemical research, preferably within a biotechnology or pharmaceutical setting. • Expertise in Synthetic/Medicinal Chemistry: You have proven expertise in modern synthetic organic chemistry, demonstrated by a strong track record of lead author publications and/or patents and an understanding of medicinal chemistry principles. • Drug Discovery Acumen: You have experience in the drug discovery process from hit identification, hit-to-lead, and lead optimization. • Structure-Based Drug Design: Experienced with structure-based drug design. • Strong Communicator: You convey strong verbal and written communication skills and a demonstrated ability to deliver effective presentations. • Problem-So