Senior Manager, Commercial Supply Chain

MISSION Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously. POSITION SUMMARY Mirum Pharmaceuticals is seeking an experienced, highly motivated, and detail-oriented Senior Manager, Commercial Supply Chain to support its growing global commercial portfolio and new product launches. This position will be primarily responsible for managing domestic and international commercial distribution, inventory management, and order-to-cash (O2C) operations to ensure timely, accurate, and compliant product delivery across global markets. In addition, the role will support end-to-end (E2E) commercial supply planning activities, including demand and supply alignment, labeling and packaging coordination, and finished product supply execution, while developing the capabilities to provide effective planning backup and ensure business continuity. The successful candidate will collaborate closely with cross-functional teams and external supply chain partners to drive operational excellence, maintain uninterrupted commercial supply, and support patient access. JOB FUNCTIONS/RESPONSIBILITIES • Lead domestic and international commercial distribution operations to ensure timely, accurate, and compliant product delivery across global markets. • Oversee order-to-cash (O2C) activities, including customer order management, inventory allocation, order fulfillment, shipment execution, and reconciliation in collaboration with Commercial Operations and Finance. • Manage commercial finished goods inventory across North American 3PLs, ensuring inventory accuracy through regular reconciliation, product availability, timely replenishment, and effective shelf-life management. • Manage relationships and operational performance of 3PLs, distributors, and logistics partners, including KPI development and monitoring, business reviews, and issue resolution. • Support new product launches, market expansion, distribution network readiness, supplier qualification, and implementation of new distribution partners • Collaborate with Quality and other cross-functional teams to ensure distribution compliance and support deviation investigations, change controls, CAPAs, and other quality-related activities, as applicable. • Drive continuous improvement of distribution, inventory management, and O2C processes through standardized procedures, system enhancements, and operational efficiencies. • Support E2E commercial supply planning activities, aligning demand, manufacturing, labeling and packaging, inventory, and distribution to ensure product availability. • Collaborate with CMOs, CPOs, and cross-functional teams to monitor manufacturing and packaging schedules, component availability, finished product readiness, and supply execution. • Support inventory projections, replenishment planning, supply-demand reconciliation, and proactive identification and mitigation of supply risks. • Participate in commercial labeling and packaging planning, including packaging readiness, market-specific supply requirements, and new product introductions. • Develop proficiency in E2E commercial planning processes, systems, and master data to provide effective backup support for supply planning and labeling and packaging activities. • Support supply chain transitions, business continuity, and continuous improvement initiatives while staying informed of regulatory changes impacting commercial supply planning and distribut