Study Physician- Neuroinflammation, Immunology Cell Therapy

Introduction to role: Are you a neurologist ready to lead a first-of-its-kind CAR-T cell therapy study that could redefine care for people living with multiple sclerosis? In this Study Physician role, you will serve as the study-level medical authority for a global, multi-cohort program in relapsing and progressive MS, directly shaping how novel immune therapies are delivered and assessed. Based at our state-of-the-art Kendall Square site in Cambridge, MA, you will work at the center of a world-leading life sciences ecosystem with direct access to collaborators, technology and patients.   You will partner closely with clinical scientists and cross-functional experts to keep patient safety at the forefront while driving decisive, data-led progress. Do you want to influence dose-escalation decisions, guide benefit-risk assessments and engage top MS investigators to accelerate a therapy that could change the trajectory of disease?   Accountabilities: • Medical Leadership and Study Design: Own the medical design, delivery and interpretation of a multi-cohort CAR-T study in MS, ensuring integrity, compliance with GCP and fast, well-reasoned decisions that move the program forward. • Medical Monitoring Across the Patient Journey: Serve as medical monitor from eligibility review through apheresis, infusion and long-term follow-up, ensuring patient safety and clinical consistency across global sites. • Safety Assessment and Governance: Lead assessment of adverse events, including CRS, ICANS, cytopenias and infections; guide dose-escalation, dose-hold and stopping-rule decisions within delegated authority; and represent the study at safety committees and internal governance. • Data Synthesis and Decision-Making: Continuously review safety, efficacy, biomarkers and data-quality trends to detect signals early, shape study adaptations and ensure robust, decision-ready data. • Clinical Adjudication: Adjudicate complex MS events, including relapse and disability progression, to secure consistent, high-quality endpoints. • Scientific Documents and Results: Provide final medical review of protocols, amendments, ICFs, IB, SAPs and CSRs; lead medical interpretation of results; and contribute to clear, compelling regulatory documentation. • External Engagement and Influence: Build strong relationships with investigators and MS experts; support investigator meetings; and contribute to regulatory interactions to align stakeholders around study priorities. • Cross-Functional Strategy: Bring MS expertise to clinical pharmacology, translational medicine, regulatory, biostatistics, safety and CMC partners to integrate science, operations and strategy. • Matrix Leadership and Mentorship: Lead through influence, escalate risks transparently and mentor colleagues to raise the bar on medical quality and delivery. • Portfolio Contribution: Provide medical input to additional neuroimmunology indications and studies as the pipeline evolves, ensuring learnings scale beyond a single program.   Essential Skills/Experience: • MD or equivalent (PhD a plus), with board certification in neurology and substantive clinical experience in multiple sclerosis. • Clinical research experience, including hands-on involvement in the design or delivery of clinical studies. • Sound knowledge of MS trial methodology and endpoints (EDSS, relapses, MRI), biostatistics principles, and FDA, EMA and ICH GCP requirements. • Ability to influence across a matrix and communicate complex decisions clearly, with a track record of delivering results.   Desirable Skills/Experience: • Biotech or pharmaceutical clinical-development experience, including oversight of industry-sponsored studies (strongly preferred). • Experience with CAR-T, other cell therapies or B-cell-depleting