Senior Research Investigator / Research Leader (Translational Pharmacology), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI. Your impact We are seeking an accomplished and visionary translational biologist to join our Translational Pharmacology team in London, working at the forefront of multidisciplinary, AI-first drug discovery. In this role, you will shape and advance our exploratory research portfolio, with an initial core focus on neurodegenerative diseases as well as adjacent high unmet need indications. Operating at the interface of disease biology, translational science, and AI-driven molecular design, you will translate deep mechanistic insights of human disease into robust therapeutic hypotheses, target validation packages, and decision-critical experimental workflows to progress programs from target identification to portfolio entry. Working shoulder-to-shoulder with world-leading machine learning researchers, computational biologists, and drug designers, you will bridge the gap between dry-lab predictive models and experimental biology—ensuring our AI platforms are grounded in disease-relevant biology and guiding next-generation medicines towards clinical reality. What you will do Therapeutic Area Strategy & Target Discovery: • Partner with therapeutic area leadership to define and evolve our neurodegeneration research strategy, identifying priority indications, emerging biological mechanisms, and high-value therapeutic opportunities. • Integrate insights across human genetics, disease pathology, clinical datasets, and advanced cellular models to critically evaluate target tractability, translational relevance, and competitive differentiation. • Drive early portfolio progression decisions by establishing rigorous go/no-go target validation criteria. Translational Biology & Experimental Execution: • Develop human disease-relevant therapeutic hypotheses that connect target modulation directly to clinically meaningful outcomes. • Translate therapeutic concep