Senior Director, Enterprise Applications

About Stoke: Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/ Position Purpose: Stoke is seeking a Senior Director, Enterprise Applications to own the company’s G&A application portfolio – NetSuite ERP, ADP HRIS and payroll, learning management (LMS), financial planning, procurement, expense, contract lifecycle management and corporate tools – and the SOX IT general controls over them. The immediate priority is leading the NetSuite extension for commercial launch (revenue, inventory, order-to-cash and CMO/3PL integration) alongside the implementation partner through 2027. This leader is the named IT partner to Finance, HR, Legal, Compliance and Internal Audit, is a member of the IT leadership team, and reports to the VP, Enterprise Technology & Architecture. Key Responsibilities: • Lead the NetSuite extension program for commercial launch (scope, design, build, data migration, testing, cutover and hypercare), including integration with CMO/CDMO, 3PL and distribution partners and any supply-planning solution layered on NetSuite; manage the implementation partner. • Own the roadmap and day-to-day operations for NetSuite, ADP and the G&A applications, from the steady stream of small enhancements and requests to enterprise-scale programs, and set the HRIS platform direction alongside the ERP program in partnership with HR. • Own the learning management system (LMS) platform in partnership with HR, Legal, Compliance and Marketing/L&D, who own curriculum and content, for onboarding, corporate and compliance training; coordinate with the Clinical & Regulatory Systems team where the platform also delivers GxP training under validated controls. • Serve as IT partner to Finance, HR, Legal, Compliance, Procurement and Internal Audit; build trusted relationships with functional leaders to understand their strategic objectives and operational challenges, translate business process needs into solutions, and lead process and system design decisions. • Drive continuous improvement by proactively identifying opportunities to streamline G&A business processes and extend system capabilities. • Own IT general controls and application controls for SOX in-scope systems: access reviews, change control, audit evidence and remediation with Internal Audit and external auditors. • Lead the Enterprise Applications team – initially a Business Systems Analyst, Financial Systems, with additional hires planned as the ERP program and commercial scope grow – and manage implementer, contractor and MSP resources as an extension of the team. • Oversee the NetSuite managed service provider: service levels, release management, escalation and ongoing optimization after go-live. • Bring AI capabilities embedded in NetSuite, ADP and the G&A platforms through the AI Steering Committee’s governance process and into use; contribute to the enterprise AI program. •