Director, Program Management

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Job Summary The Director, Program Management, will provide strategic and operational leadership for the rinvatercept (KER-065) development program. This individual will lead cross-functional program planning and execution as rinvatercept advances through clinical development. The ideal candidate will combine strong drug-development program leadership with meaningful experience running clinical trials across Phase 1, Phase 2 and Phase 3. The successful candidate will move effectively between strategic planning and hands-on execution, anticipate and mitigate risks, drive timely decisions and maintain alignment across Clinical Development, Clinical Operations, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Biometrics and other functions. Primary Responsibilities Program Strategy and Leadership • Serve as the program management lead for rinvatercept, partnering with functional leaders to define and execute the optimal global development strategy • Lead the cross-functional program team, including representatives from Clinical Development, Clinical Operations, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Biometrics, Medical Affairs, Commercial and Corporate Strategy • Guide the program through proof of concept, registration-enabling studies, regulatory submissions and potential marketing authorization • Translate development strategy into clear program objectives, operational priorities and measurable deliverables • Mobilize and align the organization around the program strategy and drive timely decision-making through appropriate governance forums • Balance day-to-day program execution with long-range strategic planning Integrated Development Planning • Create and maintain an integrated strategic development plan covering program goals, value-creation milestones, critical-path activities, cross-functional dependencies, timelines, decision points, assumptions, risks, alternative scenarios, budget and resource requirements • Ensure functional plans are aligned with the overall development strategy and that interdependencies are clearly understood and actively managed • Identify potential gaps, conflicts and constraints before they affect clinical, regulatory or operational milestones • Lead scenario planning to evaluate alternative development approaches and their implications for timeline, resources, risk and program value Clinical Development and Trial Execution • Partner with Clinical Development and Clinical Operations to plan and execute rinvatercept clinical trials across Phase 1, Phase 2 and Phase 3 • Integrate clinical activities with regulatory, CMC, nonclinical, biometrics and other program workstreams • Identify and manage dependencies affecting protocol development, regulatory submissions, site activation, patient enrollment, study conduct, data delivery and clinical readouts • Support transitions between stages of development, including progression from early clinical studies into proof-of-concept and registration-enabling trials • Apply an understanding of neuromuscular and rare-disease trial challenges, incl