Director, GI/Liver Biomarkers & Translational Research

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.   Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.   We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description   Role Overview Gilead Sciences is seeking an exceptional scientific leader to own end-to-end biomarker and translational strategy across a portfolio of inflammatory bowel disease (IBD) and liver programs. This player-coach role requires recognized scientific expertise, demonstrated productivity and the ability to translate human biology and biomarker evidence into high-impact clinical development, regulatory and portfolio decisions. The Director will establish the GI/liver biomarker roadmap, lead the most complex and strategically important programs and create leverage across assets by integrating tissue, clinical and multi-omic evidence. The role is expected to support several early and late stage programs, with assignments evolving as portfolio priorities change. This is a site based role at our global headquarters in Foster City, CA. Key Responsibilities ·    Own and continuously evolve the integrated GI/IBD and liver biomarker and translational strategy across multiple clinical-stage assets, aligning evidence generation with disease-area, asset, regulatory and portfolio objectives. ·    Lead the most complex programs from early clinical development through Phase II/III, defining decision criteria for target engagement, dose, proof-of-concept, patient selection, response, safety, differentiation and lifecycle opportunities. ·    Provide hands-on scientific leadership for analysis and interpretation of blood, stool, intestinal and liver tissue, endoscopic, histologic, imaging, pathology and multi-omic datasets. ·    Create cross-asset frameworks for forward and reverse translation, including integrated biopsy strategies and analyses of response, resistance, relapse, patient heterogeneity and mechanisms of action. ·    Lead biomarker and translational contributions to protocols, analysis plans, investigator brochures, clinical study reports, briefing documents, regulatory submissions and health authority interactions. ·    Partner with senior leaders across Clinical Development, Research, Clinical Pharmacology, Biostatistics, Bioinformatics, Diagnostics, Clinical Operations and Regulatory; clearly articulate scientific opportunities, uncertainties, trade-offs and recommendations. ·    Oversee biomarker execution, assay and vendor strategy, budgets, timelines, resources and delivery across several concurrent studies; anticipate risks and establish mitigation plans. ·    Establish collaborations with investigators, KOLs, pathologists, consortia and technology partners; represent GI/liver biomarker science at advisory boards, scientific meetings and external forums. ·    Lead publication