Principal Scientist, GI/Liver Biomarkers & Translational Research

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.   Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.   We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description   Role Overview Gilead Sciences is seeking a highly accomplished and scientifically rigorous Principal Scientist to lead biomarker and translational strategy and execution for complex clinical-stage programs across inflammatory bowel disease (IBD) and liver disease. This is a hands-on scientific leadership role for an individual who combines deep disease biology with demonstrated clinical biomarker development experience and a strong record of scientific productivity. The Principal Scientist will serve as cross-functional biomarker lead for assigned programs, translating mechanism and human biology into fit-for-purpose biomarker plans from early clinical development through Phase II/III. The role is expected to contribute across various programs, with assignments evolving as portfolio priorities change. This is a site based role at our global headquarters in Foster City, CA Key Responsibilities ·    Lead end-to-end biomarker strategy for assigned GI/IBD and liver programs, including target engagement, pharmacodynamic, mechanism-of-action, disease activity, safety, predictive and treatment-response biomarkers. ·    Translate program hypotheses into decision-focused clinical biomarker plans, sampling strategies, assay requirements, analysis plans and interpretation frameworks. ·    Provide hands-on scientific leadership for blood, stool, intestinal and liver tissue, endoscopic, histologic, imaging and multi-omic biomarker approaches. ·    Lead assay selection, characterization, qualification or validation, outsourcing, technology transfer and CRO/vendor oversight; proactively resolve scientific, quality and operational issues. ·    Partner with Clinical Development, Clinical Pharmacology, Biostatistics, Bioinformatics, Pathology, Research, Clinical Operations and Regulatory to embed biomarker objectives into protocols and development plans. ·    Lead integrated interpretation of clinical, pathology, imaging, transcriptomic, proteomic, cellular, spatial and other high-dimensional datasets; generate testable hypotheses and actionable development recommendations. ·    Drive forward and reverse translational analyses, including responder/non-responder studies and investigation of mechanisms of response, resistance, relapse and patient heterogeneity. ·    Author or provide biomarker content for protocols, investigator brochures, analysis plans, clinical study reports, briefing documents, regulatory submissions, publications and presentations. ·    Communicate complex findings clearly to program teams and governance forums; manage risks and trade-offs and influence decisions with limited guidan