Director, Project Toxicologist, Safety Sciences China

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About the role

At AstraZeneca, we push the boundaries of science to deliver life-changing medicines. Our global Safety Sciences organization delivers innovative non-clinical safety science and toxicology   expertise   to enable the discovery,   development   and registration of novel medicines.    We are   seeking   a highly motivated   Director, Project Toxicologist ,   to join our   Safety Sciences China   group.   This role will   bring non-clinical safety   expertise   and effective   discovery and regulatory   toxicology strategies to   deliver   new candidate drug   project s   (internally and/or with collaborators),   ensuring   local   preclinical safety input that integrates seamlessly into global development and submissions .   You   will   partner with   global   cross-functional teams across   therapeutic areas   and modalities   (small molecules, radio - conjugates,   immune-cell engagers,   antibody–drug conjugates,   peptides,   etc ) .   Job description   • Lead regulatory and investigative toxicology study design, developing strategies to predict, assess, and mitigate target- and modality-related safety risks.   • Apply your toxicology expertise to predict clinical safety risks and , as   core member of drug project teams,   support data-driven decisions across discovery and development programs.   • Provide strategic toxicology input for in-licensing evaluations and external collaborations.   • Communicate integrated risk assessments to governance bodies and contribute to regulatory submissions.   • Maintain and expand   expertise   in regulatory standards, preclinical safety, and modality-specific safety science, staying ahead of industry trends.   • Innovate at the intersection of regulatory toxicology and   cutting-edge   science,   leveraging   in vitro, in silico, in vivo, and emerging technologies like organ-on-chip, imaging, and omics , and c ontribute to internal and external scientific reputation   through internal and external collaborations, publications, and thought leadership .   • R ole model demonstration of AZ Values.   Essential skills and experience   • PhD and/or DABT in Toxicology, Pharmacology,   Cell Biology,   Pathology   or related field ,   with a strong scientific   track record   (or another university degree with   relevant work experience) .   • Robust   experience in Project Toxicology, Investigative Toxicology, or related   non-clinical   safety-focused roles in pharma, biotech, or CRO environments.   • Deep understanding of drug discovery and development, with proven ability to deliver toxicology programs supporting IND filings.   • Expertise   across small and large molecule modalities   and relevant therapeutic areas ( e.g.   Oncology , Cardiovascular, Metabolism, Immunology, Respiratory).   • Excellent communication, interpersonal, and influencing skills to inform decisions across scientific and regulatory teams.   Fluency in English and Mandarin is essential. Strong awareness of work-related cultural aspects across China, EU, UK,   US   and a proven ability to work across geographies and cultural barriers, building trust and effective collaboration in a global pharma environment.   • Skilled in   using in   vitro, in silico, and in vivo tools to predict clinical safety risks.   • Collaborative, problem-solving mindset with the ability to coordinate   and prioritize   across multiple projects .   Date Posted 29-9月-2026 Closing Date AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applicatio

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