Associate Principal / Principal Scientist (Protein Science)

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About the role

About GenScript Founded in 2002 in New Jersey, GenScript Biotech Corporation accelerates innovation in biotech and healthcare by providing researchers and companies with the building blocks needed to develop groundbreaking treatments and products. Guided by its mission to Make People and Nature Healthier Through Biotechnology, and its role as a well-recognized biotechnology company, GenScript has a team of approximately 6,165 employees and has served more than 200,000 customers across over 100 countries and regions. Position Overview: We are seeking a highly motivated and experienced Principal Scientist in Bispecific Antibody Design & Engineering to establish and strengthen Singapore’s role as a center of excellence for complex antibody design and molecular engineering. In this role, you will serve as a functional leader in molecular design, format selection and recommendation, and engineering strategy while enabling improved expression, developability, and manufacturability. Additionally, you will play a key role in client-facing projects, ensuring seamless collaboration and delivery of high-quality biologics solutions. This position requires a blend of platform building, leadership skills, and the ability to build cross effectively. Key Responsibilities: Biologics Production Leadership: • Develop, triage, implement, and troubleshoot innovative strategies for the design and engineering of complex antibody formats (bispecifics, multivalent, Fc-fusions, VHH). to achieve high yields, purity, and functionality. • Design and manage a portfolio of projects to provide data-driven, structure-function insights to improve expression, stability, and manufacturability. • Oversee a team of research associates and/or biotechnologists, providing technical guidance and fostering a culture of excellence in protein science methodologies. Cross-Functional Collaboration: • Collaborate with cross-functional and cross-cultural teams to support the development of biologics, with a focus on evaluate and translate new technologies into production-ready solutions. • Periodically review internal and external advancements in: • Antibody formats and engineering strategies • Upstream and downstream integration impacts driven by molecule design • Assess readiness of new technologies for tech transfer, including: • Fit-for-purpose application across different molecule classes • Scalability and reproducibility • Impact on quality attributes (aggregation, mispairing, heterogeneity) • Act as a scientific bridge between R&D innovation and operational deployment, ensuring: • New platforms are not only scientifically sound but also translatable to production workflows • Design decisions are aligned with manufacturing realities • Partner with internal stakeholders (e.g., Quality Assurance, Process Development, and Manufacturing) to ensure alignment and efficiency in biologics production workflows. Develop design-for-manufacturability strategies and internal guidelines: • Develop and integrate AI-assisted design-for-manufacturability frameworks, leveraging internal datasets and external computational tools (e.g., structure prediction, developability scoring) to proactively identify and mitigate risks such as aggregation, mispairing, and low expression in complex antibody formats. • Lead or support AI-enabled design and innovation initiatives (internal and external partnerships, including governmental or consortium projects) by translating computational design outputs into experimentally validated constructs, and ensuring alignment between in silico design predictions and real-world expression, quality, and manufacturability outcomes. Innovation & Intellectual Property : • Generate novel ideas and contribute to the company’s intellectual propert

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