Vice President, Strategic Sourcing & Procurement

About Stoke: Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/ Position Purpose: We are seeking a Vice President, Strategic Sourcing and Procurement to serve as an enterprise leader responsible for designing, scaling, and overseeing Stoke’s strategic sourcing, procurement, and supplier governance capabilities as the company expands its operations, increases headcount and prepares for potential commercialization. Reporting to the Chief Financial Officer, this executive will build a high-impact function that enables disciplined spend management, enterprise risk mitigation, operational excellence, and strong partnerships across the entire company. The VP will act as a strategic advisor to senior leadership, establish procurement governance and decision-making frameworks, lead complex supplier and contract negotiations, and ensure Stoke has the vendor infrastructure, controls, and commercial readiness required to support proper financial controls during rapid growth. Key Responsibilities: • Establish and lead the enterprise strategic sourcing and procurement function, including the operating model, governance structure, policies, systems, controls, and performance expectations required to support a growing clinical-stage and potentially commercial biotechnology company • Serve as a strategic partner to the executive team and functional leaders, advising on sourcing strategy, supplier risk, contracting priorities, spend optimization, and vendor capabilities needed to advance corporate objectives • Lead complex, high-value RFPs/RFQs/RFIs and supplier selection processes in partnership with business stakeholders, legal, finance, quality, and compliance • Oversee negotiation strategy for material agreements, ensuring favorable commercial terms, appropriate risk allocation, scalability, and alignment with business priorities • Build and manage a strategic supplier relationship management program, including executive-level vendor engagement, performance scorecards, issue escalation, corrective action planning, and lifecycle governance • Lead enterprise spend visibility and analytics, identifying opportunities for cost avoidance, savings, process efficiency, consolidation, risk mitigation, and improved forecasting • Partner with Finance and functional leaders to strengthen budget discipline, purchase-to-pay processes, contract lifecycle management, and alignment between sourcing decisions and financial planning • Establish key procurement metrics and executive reporting to monitor performance, compliance, value creation, supplier concentration, risk, and continuous improvement opportunities • Ensure procurement practices comply with applicable laws, regulations, company policies, quality expectations, and internal control requirements • Build, mentor, and scale a high-performing procurement team, fostering business partnership, ac