Principal Scientist I, Frontiers Target Champion

Job Description Summary We are seeking a highly curious, hands-on scientist to help build the next generation of opportunities for Frontier Programs within the exploratory Disease Area (DAx) in Biomedical Research. In this lab-based individual contributor role, you will shape and advance emerging opportunities across new biology and indications, moving them from early hypotheses through project initiation. Success requires initiative, comfort with ambiguity, and sound judgment to generate and interpret decision-enabling data. This role has no direct people management responsibilities but will work closely with and provide scientific guidance to junior colleagues in a matrixed setting to advance project goals.   Job Description Internal Job Title: Principal Scientist I Position Location: Cambridge, MA, onsite We are seeking a highly curious, hands-on scientist to help build the next generation of opportunities for Frontier Programs within the exploratory Disease Area (DAx) in Biomedical Research. In this lab-based individual contributor role, you will shape and advance emerging opportunities across new biology and indications, moving them from early hypotheses through project initiation. Success requires initiative, comfort with ambiguity, and sound judgment to generate and interpret decision-enabling data. This role has no direct people management responsibilities but will work closely with and provide scientific guidance to junior colleagues in a matrixed setting to advance project goals. Key Responsibilities: • Advance opportunities from biological concept through project initiation, supporting early projects through focused experimental plans and hands-on laboratory work. • Provide biological interpretation and experimental leadership for selected advancing projects, integrating internal and external data to inform strategy and decisions. • Design, execute, troubleshoot, analyze, and interpret experiments; identify critical questions and adapt plans as evidence evolves. • Align matrixed collaborators around questions, priorities, timelines, and decision criteria. • Help shape external collaborations and serve as scientific contact for academic and biotech partners. • Communicate scientific rationale, uncertainty, and concise, data-grounded recommendations to cross-functional stakeholders. • Assess emerging biology, technologies, and AI-enabled approaches, translating insights into testable hypotheses. • Mentor collaborators and trainees, providing guidance while enabling increasing independence and ownership. Essential Requirements: • PhD plus 2+ years’ relevant postdoctoral or industry experience, or BS/MS equivalent. • Demonstrated ability to independently conceive and execute experiments, interpret complex biological data, and proactively define next experiments and practical paths forward. • Understanding of early drug discovery and how experimental biology, target validation, and mechanistic evidence support project progression. • Fluency with AI-enabled workflows in research setting • Ability to influence and build relationships in matrixed, multidisciplinary teams without formal authority. • Strong communication and judgment with incomplete evidence. • Ability to guide junior researchers and trainees while maintaining high standards. • Proactive, self-directed problem solving; judgment to seek input when needed; curiosity, resilience, and willingness to challenge assumptions. Desirable Requirements: • Experience in target discovery, validation, or drug discovery across disease areas, target classes, or modalities. • Experience using AI/ML to integrate biological, translational, or multi-omics data for target identification, hypothesis generation, or opportunity prioritization. • Experience contrib